热量限制介导的急性肾损伤应激抵抗机制。
Mechanisms of Caloric Restriction-Mediated Stress-Resistance in Acute Kidney Injury.
机构信息
Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
CECAD, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
出版信息
Nephron. 2022;146(3):234-238. doi: 10.1159/000517733. Epub 2021 Aug 2.
Abstract
Caloric restriction (CR)-mediated organ protection has been shown to be extremely efficient in rodent models of acute kidney injury (AKI). Limited understanding of the underlying mechanisms paired with a risk of malnourishment and feasibility problems has hindered the translation of this immense potential to the patient setting. In this mini-review, the current mechanistic concepts of CR-mediated stress-resistance as potential key targets for renal protection in AKI will be highlighted.
摘要
热量限制（CR）介导的器官保护在急性肾损伤（AKI）的啮齿动物模型中已被证明非常有效。对潜在机制的有限理解，加上营养不足的风险和可行性问题，阻碍了将这种巨大潜力转化为患者环境。在这个迷你综述中，将重点介绍 CR 介导的应激抵抗的当前机制概念，作为 AKI 中肾脏保护的潜在关键靶点。
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