Slobodeniuk A V, Shadrin A S, Andrievskaia R A, Aleksandrova N N
Zh Mikrobiol Epidemiol Immunobiol. 1987 Nov(11):52-6.
The safety, reactogenic properties and immunogenic potency of inactivated influenza centrifuged vaccines with different hemagglutinin content were studied in observations on children aged 11-15 and 7-10 years. According to the results of clinico-laboratory investigations, commercial influenza vaccine and its variant with hemagglutinin content reduced by half were found to be safe and showed faintly pronounced reactogenic properties in children. After vaccination hyperemia developed at the site of injection, moderate in 5% of the vaccinees aged 7-10 years and mild in other vaccinees of both age groups. The immunogenic potency of the preparations was determined by the specific features of influenza virus strains: strain A (H1N1) induced seroconversion in 62-94% and strain A (H3N2), in 67-96% of children.
在对11至15岁以及7至10岁儿童的观察中，研究了不同血凝素含量的灭活流感离心疫苗的安全性、反应原性和免疫原性效力。根据临床实验室研究结果，发现市售流感疫苗及其血凝素含量减半的变体是安全的，并且在儿童中显示出轻微的反应原性。接种疫苗后，注射部位出现充血，7至10岁的接种者中有5%为中度充血，两个年龄组的其他接种者为轻度充血。制剂的免疫原性效力由流感病毒株的特定特征决定：A（H1N1）毒株在62%至94%的儿童中诱导血清转化，A（H3N2）毒株在67%至96%的儿童中诱导血清转化。
