Kolupaev G P, Iakovlev V A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1987;87(11):1723-5.
The function of the hypothalamo-pituitary-gonadal system has been studied in 118 males with different stages of alcoholism. Comparison with the control group has shown decreased levels of interstitial cell stimulating hormone (ICSH), follicle-stimulating hormone (FSH), and testosterone, and elevated concentrations of prolactin (Prl). Differences in the parameters of hormonal activity expressed in a varying degree of a decrease in FSH, ICSH, and testosterone, and a Prl elevation are related to change in mutual regulatory influences between the gonads and hypothalamo-pituitary complex. The most informative parameters were concentrations of Prl and testosterone (considering elevation in the former and reduction in the latter hormone) and the ratio of their concentrations. Difference of these parameters in each group (corresponding to the stages of alcoholism) may be used as an additional diagnostic criterion of chronic alcohol intoxication.
对118名处于不同酒精中毒阶段的男性的下丘脑 - 垂体 - 性腺系统功能进行了研究。与对照组相比，发现促间质细胞激素（ICSH）、促卵泡激素（FSH）和睾酮水平降低，而催乳素（Prl）浓度升高。激素活性参数的差异表现为FSH、ICSH和睾酮不同程度的降低以及Prl升高，这与性腺和下丘脑 - 垂体复合体之间相互调节影响的变化有关。最具信息量的参数是Prl和睾酮的浓度（考虑到前者升高和后者降低）以及它们的浓度比。每组（对应于酒精中毒阶段）这些参数的差异可用作慢性酒精中毒的附加诊断标准。
