Students Research Committee, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Experimental Medicine Research Center, Tehran University of Medical Sciences, 13145-784, Tehran, Iran.
Neurol Sci. 2021 Oct;42(10):4063-4072. doi: 10.1007/s10072-021-05508-4. Epub 2021 Aug 3.
Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disorder of the central nervous system (CNS), leading to progressive functional impairments, and many intrinsic and acquired factors are believed to be associated with its development and relapse. In terms of environmental factors, air pollution has gained much attention during recent decades, as chronic exposure to ambient air pollution seems to increase the level of some pro-inflammatory markers in the human brain, which can lead to neuroinflammation, neurodegeneration, and blood-brain barrier (BBB) breakdown. These events may also be associated with the risk of MS development and relapse. In this review, we aimed to summarize recent findings around the impact of air pollutants, including particulate matter (PM10, PM2.5, and ultra-fine particles), gaseous pollutants (carbon monoxide [CO], nitrogen oxides [NO], sulfur dioxide [SO], and ozone [O]), and heavy metals, on MS development and relapse.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎症性、自身免疫性脱髓鞘疾病，导致进行性功能障碍，许多内在和获得性因素被认为与其发生和复发有关。就环境因素而言，空气污染在近几十年来受到了广泛关注，因为慢性暴露于环境空气污染似乎会增加人脑内某些促炎标志物的水平，从而导致神经炎症、神经退行性变和血脑屏障（BBB）破裂。这些事件也可能与 MS 发生和复发的风险有关。在这篇综述中，我们旨在总结最近关于空气污染物（包括颗粒物（PM10、PM2.5 和超细颗粒）、气态污染物（一氧化碳[CO]、氮氧化物[NO]、二氧化硫[SO]和臭氧[O]）和重金属）对 MS 发生和复发的影响的研究结果。
