Ferrero Maria Elena
Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli, 31, 20133 Milan, Italy.
Biomedicines. 2022 Oct 4;10(10):2476. doi: 10.3390/biomedicines10102476.
Many mechanisms have been related to the etiopathogenesis of neurodegenerative diseases (NDs) such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and Alzheimer's disease. In this context, the detrimental role of environmental agents has also been highlighted. Studies focused on the role of toxic metals in the pathogenesis of ND demonstrate the efficacy of treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA) in eliminating toxic metal burden in all ND patients, improving their symptoms. Lead, cadmium, aluminum, nickel, and mercury were the most important toxic metals detected in these patients. Here, I provide an updated review on the damage to neurons promoted by toxic metals and on the impact of EDTA chelation therapy in ND patients, along with the clinical description of a representative case.
许多机制都与神经退行性疾病（如多发性硬化症、肌萎缩侧索硬化症、帕金森病和阿尔茨海默病）的病因发病机制相关。在此背景下，环境因素的有害作用也得到了强调。专注于有毒金属在神经退行性疾病发病机制中作用的研究表明，螯合剂乙二胺四乙酸二钠钙（EDTA）治疗在消除所有神经退行性疾病患者体内的有毒金属负担、改善其症状方面具有疗效。铅、镉、铝、镍和汞是在这些患者中检测到的最重要的有毒金属。在此，我提供了一篇关于有毒金属对神经元造成损害以及EDTA螯合疗法对神经退行性疾病患者影响的最新综述，同时还对一个典型病例进行了临床描述。
