Yang Sarah, Lee Jeonghee, Choi Il Ju, Kim Young Woo, Ryu Keun Won, Sung Joohon, Kim Jeongseon
Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Korea.
Complex Disease & Genome Epidemiology Branch, Department of Public Health, Graduate School of Public Health, Seoul National University, Seoul, Korea.
Oncotarget. 2017 Jan 24;8(4):6630-6641. doi: 10.18632/oncotarget.14250.
The effect of alcohol consumption on the risk of gastric cancer (GC) has not yet been fully elucidated, and an aldehyde dehydrogenase 2 (ALDH2) polymorphism, rs671, is a genetic variant that influences alcohol consumption in East Asians. Additionally, the discrepancy between the Helicobacter pylori (H. pylori) infection prevalence and GC incidence across Asian countries has not been explained. This study evaluated the effects of alcohol consumption and genetic susceptibility to defective acetaldehyde metabolism on the GC risk and their interactions with H. pylori infection. This study included 450 Korean GC cases and 1,050 controls recruited at the National Cancer Center. Data for 795 patients and 4,893 controls were used for further confirmation of the effect of rs671. Increased GC risks were evident for rs671 A allele carriers (odds ratio (OR), 1.23; 95% confidence interval (CI), 1.08-1.41) and H. pylori-infected individuals (OR, 7.07; 95% CI, 4.60-10.86), but no dose-response association with alcohol consumption was observed. Furthermore, the interactions between these factors were not significant. This study has demonstrated that alcohol consumption and rs671 should be considered simultaneously when assessing the GC risk. Additionally, alcohol-related factors were not found to interact with H. pylori infection, and further studies evaluating other environmental factors are required to explain the Asian enigma.
饮酒对胃癌（GC）风险的影响尚未完全阐明，而醛脱氢酶2（ALDH2）基因多态性rs671是一种影响东亚人饮酒量的基因变异。此外，亚洲国家间幽门螺杆菌（H. pylori）感染率与GC发病率之间的差异尚未得到解释。本研究评估了饮酒及乙醛代谢缺陷的遗传易感性对GC风险的影响及其与H. pylori感染的相互作用。本研究纳入了在国立癌症中心招募的450例韩国GC病例和1050例对照。795例患者和4893例对照的数据用于进一步确认rs671的作用。rs671 A等位基因携带者（优势比（OR），1.23；95%置信区间（CI），1.08 - 1.41）和H. pylori感染个体（OR，7.07；95% CI，4.60 - 10.86）的GC风险明显增加，但未观察到饮酒量与GC风险的剂量反应关系。此外，这些因素之间的相互作用不显著。本研究表明，在评估GC风险时应同时考虑饮酒和rs671。此外，未发现饮酒相关因素与H. pylori感染相互作用，需要进一步研究评估其他环境因素以解释亚洲谜团。
