从密花轮环藤的树皮中分离得到的单萜吲哚生物碱。
Monoterpenoid indole alkaloids from the bark of Melodinus henryi.
机构信息
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education (South-Central University for Nationalities), China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, Hubei 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education (South-Central University for Nationalities), China.
出版信息
Fitoterapia. 2019 Oct;138:104354. doi: 10.1016/j.fitote.2019.104354. Epub 2019 Aug 30.
Four new alkaloids, melodinines W-W (1-4), together with twenty one known alkaloids (5-25) were isolated from Melodinus henryi. The structures with absolute configurations were elucidated by extensive MS and NMR spectroscopic methods, as well as the single crystal X-ray diffraction and ECD calculations. All compounds were evaluated for their cytotoxicities to five human cancer cell lines. Many compounds showed certain cytotoxicities to five human cancer cell lines with an IC range of 1.4-29.4 μM.
从密花八角中分离得到四个新生物碱，即 melodinines W-W（1-4），以及二十一个已知生物碱（5-25）。通过广泛的 MS 和 NMR 光谱方法，以及单晶 X 射线衍射和 ECD 计算，确定了它们的结构和绝对构型。所有化合物均对五种人癌细胞系进行了细胞毒性评价。许多化合物对五种人癌细胞系具有一定的细胞毒性，IC 范围为 1.4-29.4 μM。
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