泰国1型糖尿病儿童和青少年中双酚A水平升高。

Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus.

作者信息

Tosirisuk Naruporn, Sakorn Natee, Jantarat Chutima, Nosoongnoen Wichit, Aroonpakmongkol Suphab, Supornsilchai Vichit

机构信息

Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

School of Pharmacy, Walailak University, Nakhon Si Thammarat, Thailand.

出版信息

Pediatr Int. 2022 Jan;64(1):e14944. doi: 10.1111/ped.14944.

DOI:10.1111/ped.14944

PMID:34342913

Abstract

BACKGROUND

The incidence of type 1 diabetes mellitus (T1DM) in children and adolescents continues to increase worldwide. The reason for this is unclear. In addition to the role of genetics, bisphenol A (BPA) has been investigated as a possible causal factor for T1DM. This study aimed to determine the correlation between urinary BPA levels and T1DM in Thai children and adolescents.

METHODS

A cross-sectional study was conducted in T1DM patients who were followed at the endocrinology clinic at King Chulalongkorn Memorial Hospital from December 2018 to December 2019 and age-matched healthy controls. Urinary BPA levels were analyzed by high-performance liquid chromatography and adjusted by urine creatinine. Anthropometric data were measured in all participants and clinical data were collected for the T1DM patients. All participants completed a questionnaire regarding possible BPA exposures. Multivariate logistic regression analysis was used to estimate the adjusted odds ratio for T1DM.

RESULTS

Seventy-five T1DM patients and 113 age-matched controls were included in the study. The mean age for T1DM and control groups were 14.8 ± 5.7 and 14.4 ± 6.2 years, respectively. The T1DM group had a significantly higher median (interquartile range) level of adjusted urinary BPA compared to the control (31.50 [7.87, 69.45] vs 10.1 [0, 54.01] μg/g creatinine, P = 0.02). Urinary BPA of 17 μg/g creatinine or more was significantly associated with TIDM, with adjusted odds ratio (95% Confident interval, CI) of 2.38 (1.27, 4.44), P = 0.006.

CONCLUSIONS

Higher urinary BPA level is one of the possible risk factors for T1DM.

摘要

背景

全球范围内，儿童和青少年1型糖尿病（T1DM）的发病率持续上升。其原因尚不清楚。除了遗传因素外，双酚A（BPA）已被作为T1DM的一个可能致病因素进行研究。本研究旨在确定泰国儿童和青少年尿中双酚A水平与T1DM之间的相关性。

方法

对2018年12月至2019年12月在朱拉隆功国王纪念医院内分泌门诊随访的T1DM患者及年龄匹配的健康对照进行横断面研究。采用高效液相色谱法分析尿中双酚A水平，并以尿肌酐进行校正。测量所有参与者的人体测量数据，并收集T1DM患者的临床数据。所有参与者均完成了一份关于可能的双酚A暴露情况的问卷。采用多因素logistic回归分析来估计T1DM的校正比值比。

结果

本研究纳入了75例T1DM患者和113例年龄匹配的对照。T1DM组和对照组的平均年龄分别为14.8±5.7岁和14.4±6.2岁。与对照组相比，T1DM组校正后的尿双酚A中位数（四分位间距）水平显著更高（31.50 [7.87, 69.45] vs 10.1 [0, 54.01] μg/g肌酐，P = 0.02）。尿双酚A水平≥17 μg/g肌酐与T1DM显著相关，校正比值比（95%可信区间，CI）为2.38（1.27, 4.44），P = 0.006。