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1
Association between urinary concentrations of bisphenol A substitutes and diabetes in adults.成人尿液中双酚A替代物浓度与糖尿病之间的关联。
World J Diabetes. 2022 Jul 15;13(7):521-531. doi: 10.4239/wjd.v13.i7.521.
2
Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults.尿液双酚 A 及其替代品双酚 S 和 F 浓度与成年人抑郁症状的关联。
Chemosphere. 2021 Sep;279:130573. doi: 10.1016/j.chemosphere.2021.130573. Epub 2021 Apr 14.
3
Exposure to Bisphenol A, Bisphenol F, and Bisphenol S in U.S. Adults and Children: The National Health and Nutrition Examination Survey 2013-2014.美国成年人和儿童体内双酚A、双酚F和双酚S的暴露情况：2013 - 2014年国家健康与营养检查调查
ACS Omega. 2018 Jun 30;3(6):6523-6532. doi: 10.1021/acsomega.8b00824. Epub 2018 Jun 18.
4
Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study.美国成年人中的双酚A替代品与肥胖：一项基于人群的横断面研究分析
Lancet Planet Health. 2017 Jun;1(3):e114-e122. doi: 10.1016/S2542-5196(17)30049-9.
5
Associations of bisphenol F and S, as substitutes for bisphenol A, with cardiovascular disease in American adults.双酚F和双酚S作为双酚A的替代品与美国成年人心血管疾病的关联。
J Appl Toxicol. 2023 Apr;43(4):500-507. doi: 10.1002/jat.4401. Epub 2022 Oct 11.
6
Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review.双酚 A 替代品、双酚 S 和双酚 F 的暴露及其与肥胖和糖尿病发病的关系：叙述性综述。
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Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea.韩国 6 岁儿童甲状腺激素水平与尿液中双酚 A、F 和 S 浓度的相关性。
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Association of Bisphenol A and Its Substitutes, Bisphenol F and Bisphenol S, with Obesity in United States Children and Adolescents.双酚 A 及其替代品双酚 F 和双酚 S 与美国儿童和青少年肥胖的关联。
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Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults.双酚 S、双酚 F、双酚 A 暴露与美国成年人的身体成分。
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Relation of urinary bisphenol concentration and diabetes or prediabetes in French adults: A cross-sectional study.法国成年人尿液双酚浓度与糖尿病或糖尿病前期的关系：一项横断面研究。
PLoS One. 2023 Mar 30;18(3):e0283444. doi: 10.1371/journal.pone.0283444. eCollection 2023.

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1
Dermal absorption, skin retention and urinary elimination of bisphenol S in rats: in vitro, in vivo and intravenous comparative analysis.大鼠中双酚S的皮肤吸收、皮肤滞留和尿排泄：体外、体内和静脉注射的对比分析。
Arch Toxicol. 2025 Jul 23. doi: 10.1007/s00204-025-04138-5.
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The Hidden Threat: Endocrine Disruptors and Their Impact on Insulin Resistance.隐藏的威胁：内分泌干扰物及其对胰岛素抵抗的影响。
Cureus. 2023 Oct 18;15(10):e47282. doi: 10.7759/cureus.47282. eCollection 2023 Oct.
3
New environmental factors related to diabetes risk in humans: Emerging bisphenols used in synthesis of plastics.与人类糖尿病风险相关的新环境因素：合成塑料中使用的新兴双酚类物质。
World J Diabetes. 2023 Aug 15;14(8):1301-1313. doi: 10.4239/wjd.v14.i8.1301.
4
Endocrine disruptors in plastics alter β-cell physiology and increase the risk of diabetes mellitus.塑料中的内分泌干扰物改变β细胞的生理学特性，并增加糖尿病的患病风险。
Am J Physiol Endocrinol Metab. 2023 Jun 1;324(6):E488-E505. doi: 10.1152/ajpendo.00068.2023. Epub 2023 May 3.

本文引用的文献

1
Comparison of the renal effects of bisphenol A in mice with and without experimental diabetes. Role of sexual dimorphism.比较有和没有实验性糖尿病的小鼠中双酚 A 的肾脏作用。性别二态性的作用。
Biochim Biophys Acta Mol Basis Dis. 2022 Jan 1;1868(1):166296. doi: 10.1016/j.bbadis.2021.166296. Epub 2021 Oct 27.
2
Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.双酚 A 可诱导小鼠血管内皮细胞加速衰老。
Biomolecules. 2021 Sep 29;11(10):1429. doi: 10.3390/biom11101429.
3
Increased bisphenol A levels in Thai children and adolescents with type 1 diabetes mellitus.泰国1型糖尿病儿童和青少年中双酚A水平升高。
Pediatr Int. 2022 Jan;64(1):e14944. doi: 10.1111/ped.14944.
4
Associations of urinary bisphenol A and its alternatives bisphenol S and F concentrations with depressive symptoms among adults.尿液双酚 A 及其替代品双酚 S 和 F 浓度与成年人抑郁症状的关联。
Chemosphere. 2021 Sep;279:130573. doi: 10.1016/j.chemosphere.2021.130573. Epub 2021 Apr 14.
5
Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion channel expression and activity and insulin release through an estrogen receptor ERβ mediated pathway.双酚 S 和双酚 F 通过雌激素受体 ERβ 介导的途径改变小鼠胰腺β 细胞离子通道的表达和活性以及胰岛素释放。
Chemosphere. 2021 Feb;265:129051. doi: 10.1016/j.chemosphere.2020.129051. Epub 2020 Nov 20.
6
Effects of bisphenol A on cardiovascular disease: An epidemiological study using National Health and Nutrition Examination Survey 2003-2016 and meta-analysis.双酚 A 对心血管疾病的影响：基于 2003-2016 年全国健康与营养调查的流行病学研究和荟萃分析。
Sci Total Environ. 2021 Apr 1;763:142941. doi: 10.1016/j.scitotenv.2020.142941. Epub 2020 Oct 14.
7
Bisphenol A impaired cell adhesion by altering the expression of adhesion and cytoskeleton proteins on human podocytes.双酚 A 通过改变人足细胞黏附及细胞骨架蛋白的表达而影响细胞黏附。
Sci Rep. 2020 Oct 6;10(1):16638. doi: 10.1038/s41598-020-73636-6.
8
Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway.双酚 A 通过激活 RIP3/CamKII 依赖性通路诱导冠状动脉内皮细胞坏死性凋亡。
Sci Rep. 2020 Mar 6;10(1):4190. doi: 10.1038/s41598-020-61014-1.
9
The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor.双酚衍生物对雌激素受体和雄激素受体的混合物效应。
Environ Pollut. 2020 May;260:114036. doi: 10.1016/j.envpol.2020.114036. Epub 2020 Jan 21.
10
Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes.双酚 F 和 S（用作双酚 A 替代品）的尿液水平与哮喘和花粉热结局的关联。
Environ Res. 2020 Apr;183:108944. doi: 10.1016/j.envres.2019.108944. Epub 2019 Nov 22.

成人尿液中双酚A替代物浓度与糖尿病之间的关联。

Association between urinary concentrations of bisphenol A substitutes and diabetes in adults.

作者信息

Moreno-Gómez-Toledano Rafael, Vélez-Vélez Esperanza, Arenas María I, Saura Marta, Bosch Ricardo J

机构信息

Universidad de Alcalá, Department of Biological Systems/Physiology Unit, Alcalá de Henares 28871, Spain.

Fundación Jiménez Díaz School of Nursing, Jiménez Díaz Foundation, Autonomous University of Madrid, Madrid 28040, Spain.

出版信息

World J Diabetes. 2022 Jul 15;13(7):521-531. doi: 10.4239/wjd.v13.i7.521.

DOI:10.4239/wjd.v13.i7.521
PMID:36051427
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9329846/
Abstract

BACKGROUND

Due to new restrictions on the use of bisphenol A (BPA), industries are beginning to replace it with derived molecules such as bisphenol S and F (BPS and BPF). There is extensive evidence in the academic literature on the potential health effects of BPA, which is known to be a diabetogenic molecule. However, there are few publications related to new compounds derived from BPA.

AIM

To perform an epidemiological study of urinary BPS and BPF in the American National Health and Nutrition Examination Survey (NHANES) cohort, and analyze their possible relationship with diabetes mellitus.

METHODS

NHANES datasets from 2013 to 2016 were used due to the urinary BPF and BPS availability. Data from 3658 adults were analyzed to perform regression analysis exploring the possible relationship between BPA-derived compounds and diabetes.

RESULTS

Descriptive statistics, linear regression modeling, and logistic regression analysis revealed a significant relationship between urinary BPS, but not BPF, and diabetes risk. Additionally, a relationship was observed between both compounds and hypertension and a slight relationship between BPF and dyslipidemia.

CONCLUSION

In the present study, a strong relationship between urinary BPS, not BPF, and diabetes risk has been determined. BPA substitute molecules do not exempt the population from potential health risks.

摘要

背景

由于对双酚A（BPA）使用的新限制，工业界开始用双酚S和F（BPS和BPF）等衍生分子来替代它。学术文献中有大量关于BPA潜在健康影响的证据，已知BPA是一种致糖尿病分子。然而，关于BPA衍生的新化合物的相关出版物很少。

目的

在美国国家健康与营养检查调查（NHANES）队列中对尿中BPS和BPF进行流行病学研究，并分析它们与糖尿病之间可能的关系。

方法

由于可获得尿中BPF和BPS的数据，使用了2013年至2016年的NHANES数据集。对3658名成年人的数据进行分析，以进行回归分析，探讨BPA衍生化合物与糖尿病之间的可能关系。

结果

描述性统计、线性回归建模和逻辑回归分析显示，尿中BPS与糖尿病风险之间存在显著关系，但BPF与糖尿病风险之间不存在显著关系。此外，观察到这两种化合物与高血压之间存在关系，BPF与血脂异常之间存在轻微关系。

结论

在本研究中，已确定尿中BPS而非BPF与糖尿病风险之间存在密切关系。BPA替代分子并不能使人群免除潜在的健康风险。