Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Food Chem Toxicol. 2021 Oct;156:112447. doi: 10.1016/j.fct.2021.112447. Epub 2021 Jul 31.
Recently, the cultivation of light Cannabis, with a total THC content less than 0.6%, has been encouraged due to its industrial and therapeutic potential. This has increased the consumption of hemp for both smoking purposes and food preparation. Even so, Cannabis inflorescences are not subject to EU regulations and standards provided for food and tobacco products. A study was carried out on thirty-one inflorescences samples, collected in different Italian regions, in order to determine cannabinoids, pesticides and metals and to evaluate the exposure of consumers to contaminants and ensure a safe consumption. Contents of THC were always below 0.5%, while CBD ranged between 0.3 and 8.64%. The determination of 154 pesticides showed that 87% of the samples contained fungicides and insecticides in the range 0.01-185 μg/g. The most found are spinosad and cyprodinil. The concentration of metals ranged from 1 to more than 100 μg/g and As, Cd, Co, Cr, Hg, Cu, Mo, Ni and V exceeded the regulatory US limits for inhaled Cannabis products, while Pb exceeded them for both oral and inhaled products. These contaminants are intrinsically toxic and may affect public health. Actions are needed to establish regulatory measures and reduce the adverse effects caused by contaminants in Cannabis.
最近，由于其工业和治疗潜力，总四氢大麻酚（THC）含量低于 0.6%的低浓度大麻的种植得到了鼓励。这增加了大麻用于吸烟和食品制备的消费。即便如此，大麻花序不受欧盟为食品和烟草产品规定的法规和标准的约束。对在意大利不同地区收集的 31 个花序样本进行了研究，以确定大麻素、农药和金属，并评估消费者接触污染物的情况，确保安全消费。THC 的含量始终低于 0.5%，而 CBD 在 0.3 至 8.64%之间。对 154 种农药的测定表明，87%的样品中含有浓度在 0.01-185μg/g 之间的杀菌剂和杀虫剂。最常见的是多杀菌素和螺虫乙酯。金属的浓度范围从 1 到 100 多μg/g，As、Cd、Co、Cr、Hg、Cu、Mo、Ni 和 V 超过了美国对吸入用大麻产品的监管限量，而 Pb 对口服和吸入用产品都超过了限量。这些污染物具有内在毒性，可能会影响公共健康。需要采取行动来制定监管措施，减少大麻中污染物造成的不良影响。
