Reznik Ed, Jiang Hui, Hakimi A Ari
Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
Cancer Discov. 2021 Aug;11(8):1879-1880. doi: 10.1158/2159-8290.CD-21-0610.
Obesity is both a risk factor for the development of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC), and a prognostically protective factor for clinical outcomes. In this issue of , Tan and colleagues identify the tumor- and adipose-derived adipokine chemerin as a circulating mediator of ccRCC lipid metabolism and ferroptotic susceptibility that may clarify the paradoxical relationship between ccRCC and obesity..
肥胖既是最常见的肾癌——透明细胞肾细胞癌（ccRCC）发生发展的危险因素，也是临床结局的预后保护因素。在本期杂志中，Tan及其同事确定肿瘤和脂肪来源的脂肪因子趋化素是ccRCC脂质代谢和铁死亡易感性的循环介质，这可能有助于阐明ccRCC与肥胖之间看似矛盾的关系。
