从聚集诱导猝灭到聚集诱导发光的调控：寻找用于癌症治疗的生物相容性聚合物诊疗平台。
Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy.
作者信息
Wang Cheng, Wang Ziyu, Chen Shaoqing, Cui Pengfei, Qiu Lin, Zhou Shuwen, Jiang Hua, Jiang Pengju, Wang Jianhao
机构信息
School of Pharmacy, Changzhou University, Changzhou, Jiangsu, 213164, China.
State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, 199 Ren'ai Road, Suzhou, 215123, P. R. China.
出版信息
Macromol Rapid Commun. 2021 Oct;42(19):e2100264. doi: 10.1002/marc.202100264. Epub 2021 Aug 12.
Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.
通过铃木耦合合成了双分子内荧光共振能量转移聚合物，通过调节电荷比可以方便地调节其从聚集导致猝灭（ACQ）到聚集诱导发光（AIE）的发光特性。最终获得的AIE聚合物进一步用于构建负载阿霉素的纳米颗粒，作为一种有前途的癌症治疗诊断平台。
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