Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, The University of Arizona, Tucson, AZ, United States of America.
School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, United States of America.
PLoS One. 2021 Aug 4;16(8):e0254347. doi: 10.1371/journal.pone.0254347. eCollection 2021.
Clinical presentation, outcomes, and duration of COVID-19 has ranged dramatically. While some individuals recover quickly, others suffer from persistent symptoms, collectively known as long COVID, or post-acute sequelae of SARS-CoV-2 (PASC). Most PASC research has focused on hospitalized COVID-19 patients with moderate to severe disease. We used data from a diverse population-based cohort of Arizonans to estimate prevalence of PASC, defined as experiencing at least one symptom 30 days or longer, and prevalence of individual symptoms. There were 303 non-hospitalized individuals with a positive lab-confirmed COVID-19 test who were followed for a median of 61 days (range 30-250). COVID-19 positive participants were mostly female (70%), non-Hispanic white (68%), and on average 44 years old. Prevalence of PASC at 30 days post-infection was 68.7% (95% confidence interval: 63.4, 73.9). The most common symptoms were fatigue (37.5%), shortness-of-breath (37.5%), brain fog (30.8%), and stress/anxiety (30.8%). The median number of symptoms was 3 (range 1-20). Amongst 157 participants with longer follow-up (≥60 days), PASC prevalence was 77.1%.
COVID-19 的临床表现、结果和持续时间差异很大。虽然有些人恢复得很快，但也有一些人患有持续的症状，统称为长新冠或 SARS-CoV-2 的急性后期后遗症（PASC）。大多数 PASC 研究都集中在患有中度至重度疾病的住院 COVID-19 患者上。我们使用来自亚利桑那州多样化人群的队列数据来估计 PASC 的患病率，定义为至少出现一种症状持续 30 天或更长时间，以及个别症状的患病率。有 303 名未住院的实验室确诊 COVID-19 检测呈阳性者接受了中位数为 61 天（范围 30-250 天）的随访。COVID-19 阳性参与者主要为女性（70%）、非西班牙裔白人（68%），平均年龄为 44 岁。感染后 30 天 PASC 的患病率为 68.7%（95%置信区间：63.4，73.9）。最常见的症状是疲劳（37.5%）、呼吸急促（37.5%）、脑雾（30.8%）和压力/焦虑（30.8%）。症状中位数为 3 种（范围 1-20）。在 157 名随访时间更长（≥60 天）的参与者中，PASC 的患病率为 77.1%。
