日本人群中β3-肾上腺素能受体基因Trp64Arg多态性、高血压与胰岛素抵抗之间的关系。

Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population.

作者信息

Yamada Youhei, Nakamura Haruki, Tsujiguchi Hiromasa, Hara Akinori, Miyagi Sakae, Kannon Takayuki, Sato Takehiro, Hosomichi Kazuyoshi, Nguyen Thao Thi Thu, Kambayashi Yasuhiro, Shimizu Yukari, Pham Kim Oanh, Suzuki Keita, Suzuki Fumihiko, Kasahara Tomoko, Tsuboi Hirohito, Tajima Atsushi, Nakamura Hiroyuki

机构信息

Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

Department of Public Health, Kanazawa University Graduate School of Advanced Preventive Medical Sciences, Kanazawa, Japan.

出版信息

PLoS One. 2021 Aug 4;16(8):e0255444. doi: 10.1371/journal.pone.0255444. eCollection 2021.

DOI:10.1371/journal.pone.0255444

PMID:34347822

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8336805/

Abstract

A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.

摘要

ADRB3基因中的一种多态性（色氨酸64精氨酸）与肥胖、胰岛素抵抗和高血压有关。这项横断面研究调查了719名40岁及以上日本受试者中这种多态性、高血压和胰岛素抵抗值（HOMA-IR）之间的关系。色氨酸64色氨酸（纯合子，野生型）、色氨酸64精氨酸（杂合子，变异型）和精氨酸64精氨酸（纯合子，变异型）的基因型频率分别为466（65%）、233（32%）和20（3%）。在日本人群中，胰岛素抵抗与高血压风险增加有关。这种关系取决于色氨酸64精氨酸多态性的存在与否（比值比，2.054；置信区间，1.191至3.541；P值，0.010）。因此，在健康的日本人群中，ADRB3基因的色氨酸64精氨酸多态性与高血压和胰岛素抵抗有关。这种依赖于多态性的关系可能预测高血压和糖尿病的发生。