Strazzullo P, Iacone R, Siani A, Cappuccio F P, Russo O, Barba G, Barbato A, D'Elia L, Trevisan M, Farinaro E
Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Italy.
J Hypertens. 2001 Mar;19(3):399-406. doi: 10.1097/00004872-200103000-00007.
The association of the Trp64Arg polymorphism of the beta3-adrenoceptor (beta3-AR) gene with high blood pressure, central adiposity and other features of the metabolic syndrome was investigated in a large unselected sample of a white male working population in Southern Italy (n = 979).
In the whole population, subjects heterozygous for the Trp64Arg mutation (11.2%) were not different from the homozygous Trp64Trp for any of the variables investigated. However, upon stratification for age, among men in the upper tertile of age (> 53 years), the Trp64Arg genotype was associated with higher waist: hip ratio (0.992 +/- 0.021 versus 0.982 +/- 0.037, P< 0.05), serum uric acid (6.34 +/- 1.50 versus 5.75 +/- 1.30 micromol/l, P < 0.05) and systolic blood pressure (144.3 +/- 19.4 versus 136.9 +/- 18.9 mmHg, P< 0.05) compared with the wild-type homozygotes. Accordingly, in the same age group, the carriers of Trp64Arg genotype were more often in the upper tertile of abdominal adiposity (69.7 versus 43.7%, P< 0.02) and serum uric acid (56.3 versus 34.8%, P < 0.02) and were more often hypertensive (68.6 versus 57.6%, P< 0.058) than the Trp64Trp homozygotes. No such differences were observed in younger age groups. No association was found with fasting serum insulin and the homeostasis model assessment (HOMA) index of insulin resistance. Furthermore, in a subgroup of 457 men for whom retrospective 20-year follow-up data were available, the variant genotype was associated with a higher probability of developing overweight (44.7 versus 27.0%, P < 0.05) and a trend to higher blood pressure (52.6 versus 38.4%, P = 0.09) over 20 years.
We conclude that the Trp64Arg variant of the beta3-AR receptor predicts a greater tendency to develop abdominal adiposity and high blood pressure with advancing age.
在意大利南部一个未经过挑选的白种男性工作人群的大样本（n = 979）中，研究β3 - 肾上腺素能受体（β3 - AR）基因的色氨酸64精氨酸（Trp64Arg）多态性与高血压、中心性肥胖及代谢综合征其他特征之间的关联。
在整个人群中，Trp64Arg突变杂合子（11.2%）在任何所研究的变量方面与Trp64Trp纯合子均无差异。然而，按年龄分层后，在年龄处于上三分位数（> 53岁）的男性中，与野生型纯合子相比，Trp64Arg基因型与更高的腰臀比（0.992 ± 0.021对0.982 ± 0.037，P < 0.05）、血清尿酸（6.34 ± 1.50对5.75 ± 1.30 μmol/L，P < 0.05）和收缩压（144.3 ± 19.4对136.9 ± 18.9 mmHg，P < 0.05）相关。因此，在同一年龄组中，Trp64Arg基因型携带者在腹部肥胖上三分位数的比例更高（69.7%对43.7%，P < 0.02），血清尿酸上三分位数的比例更高（56.3%对34.8%，P < 0.02），且高血压的比例更高（68.6%对57.6%，P < 0.058），均高于Trp64Trp纯合子。在较年轻年龄组中未观察到此类差异。未发现与空腹血清胰岛素及胰岛素抵抗的稳态模型评估（HOMA）指数有关联。此外，在一个有457名男性的亚组中，可获得其20年回顾性随访数据，该变异基因型与20年内发生超重的较高概率相关（44.7%对27.0%，P < 0.05），且有血压升高的趋势（52.6%对38.4%，P = 0.09）。
我们得出结论，β3 - AR受体的Trp64Arg变异预示着随着年龄增长，发生腹部肥胖和高血压的倾向更大。
