Centro de Investigación, Innovación y Desarrollo de Materiales CIDEMAT, Facultad de Ingeniería, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.
Crit Rev Biomed Eng. 2021;49(1):51-65. doi: 10.1615/CritRevBiomedEng.2021037758.
Titanium dioxide nanotubes combine the geometrical properties of a tubular structure with the physico-chemical properties of TiO2. The nanotubes improve the surface characteristics of a material such as titanium, which possesses high mechanical resistance, and low density, enhancing its use for biomedical devices. The nanotubular layer increases the device's interaction with cells. In this paper, we discuss various aspects of the anodizing technique to obtain ordered nanotubes and careful control of the process parameters to obtain highly ordered TiO2 nanotubes. Also, we review the biological activity of TiO2 nanotubes, the effect of nanotube size on bioactivity, and the antibacterial effect of TiO2 nanotubes without doping. Finally, novel applications of TiO2 nanotubes employed as a biomaterial are discussed.
二氧化钛纳米管结合了管状结构的几何特性和 TiO2 的物理化学特性。纳米管改善了材料的表面特性，如钛，钛具有高机械强度和低密度，这增强了其在生物医学设备中的应用。纳米管层增加了器件与细胞的相互作用。在本文中，我们讨论了获得有序纳米管的阳极氧化技术的各个方面，并对工艺参数进行了仔细控制，以获得高度有序的 TiO2 纳米管。此外，我们还综述了 TiO2 纳米管的生物活性、纳米管尺寸对生物活性的影响以及未掺杂的 TiO2 纳米管的抗菌效果。最后，讨论了作为生物材料的 TiO2 纳米管的新应用。
