Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, China.
Appl Microbiol Biotechnol. 2020 Apr;104(7):2947-2955. doi: 10.1007/s00253-020-10446-w. Epub 2020 Feb 13.
The anodized titanium nanotubes (TiO-NTs) are considered to be a potential material in clinical therapy. To enhance the antibacterial property of TiO-NTs, cefuroxime is introduced into TiO-NTs, and then, different chitosan layers are coated to control the release of cefuroxime. SEM and FTIR are adapted for the characterization of prepared TiO-NTs. The effects of chitosan coating thickness on release of cefuroxime are also investigated, followed with the antibacterial property evaluation. The results show TiO-NTs are fabricated by anodization method and cefuroxime is also successfully loaded into the nanotubes. The thickness of chitosan coating is an important factor to the release rate of cefuroxime. Antimicrobial detection and morphology observation of S. aureus show a sustained 7-day drug release and strong negative effect on bacteria. The approach in this study provides a broadly applicable method to fabricate titanium-based orthopedic implants with enhanced antibacterial properties.
经过阳极氧化处理的钛纳米管（TiO-NTs）被认为是一种有潜力的临床治疗材料。为了提高 TiO-NTs 的抗菌性能，将头孢呋辛引入 TiO-NTs 中，然后涂覆不同厚度的壳聚糖层以控制头孢呋辛的释放。采用 SEM 和 FTIR 对制备的 TiO-NTs 进行了表征。还研究了壳聚糖涂层厚度对头孢呋辛释放的影响，并进行了抗菌性能评价。结果表明，采用阳极氧化法制备了 TiO-NTs，并且成功地将头孢呋辛载入纳米管中。壳聚糖涂层的厚度是影响头孢呋辛释放速率的一个重要因素。对金黄色葡萄球菌的抗菌检测和形态观察表明，药物能够持续释放 7 天，并且对细菌有很强的抑制作用。本研究提供了一种广泛适用于制备具有增强抗菌性能的基于钛的骨科植入物的方法。
