单纯唇裂和/或腭裂患儿及青年大脑发育轨迹。
Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate.
机构信息
Department of Psychological and Quantitative Foundations, University of Iowa College of Education, USA.
Department of Psychiatry, University of Iowa Carver College of Medicine, USA.
出版信息
Dev Neuropsychol. 2021 Jul;46(4):314-326. doi: 10.1080/87565641.2021.1946691. Epub 2021 Aug 4.
Abstract
The present study evaluated brain development in persons with isolated cleft lip and/or cleft palate (iCL/P) compared to unaffected controls using an accelerated longitudinal design. A sample of 134 males and females, ages 7-27 years, with iCL/P (184 observations, total) was compared to 144 unaffected controls (208 evaluations, total) on Wechsler Index scores and volumetric data from structural MRI scans. Boys with isolated cleft palate had verbal IQ 15.5 points lower than perceptual IQ; a clinically significant difference. Participants with iCL/P had differential growth trajectories of regional cerebrum matter and consistently lower volumes of cerebellar gray matter and subcortical matter.
摘要
本研究采用加速纵向设计，评估了单纯唇裂和/或腭裂（iCL/P）患者与正常对照者的脑发育情况。该研究纳入了 134 名年龄在 7-27 岁的男性和女性 iCL/P 患者（共 184 个观察值），并将其与 144 名正常对照者（共 208 个评估值）的韦氏智力指数评分和结构 MRI 扫描的容积数据进行比较。单纯腭裂男孩的言语智商比知觉智商低 15.5 分；这是一个具有临床意义的差异。iCL/P 患者的大脑区域存在不同的生长轨迹，且小脑灰质和皮质下灰质的体积也一直较低。
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