以不愉快的音符结束：脂质在癌症中协调铁死亡。
Ending on a sour note: Lipids orchestrate ferroptosis in cancer.
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
出版信息
Cell Metab. 2021 Aug 3;33(8):1507-1509. doi: 10.1016/j.cmet.2021.07.011.
Lipid metabolism is altered in the acidic tumor microenvironment. Here, the authors show that polyunsaturated fatty acid supplementation, together with concomitant inhibition of lipid droplet biogenesis, induces ferroptosis in acidic cancer cells. These findings highlight the potential to exploit cancer dependence on exogenous lipids as a therapeutic vulnerability.
脂质代谢在酸性肿瘤微环境中发生改变。在这里，作者表明，多不饱和脂肪酸的补充，加上同时抑制脂滴的生物发生，可诱导酸性癌细胞发生铁死亡。这些发现强调了利用癌症对外源脂质的依赖性作为治疗弱点的潜力。
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