Shi Jing-Fen, Liu Yu'e, Wang Yan, Gao Ru, Wang Yi, Liu Jun
Institute for Health Policy and Hospital Management, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wenjiang District People's Hospital of Chengdu, Chengdu, China.
Front Pharmacol. 2023 May 5;14:1194343. doi: 10.3389/fphar.2023.1194343. eCollection 2023.
Ferroptosis is a new iron-dependent cell death mode, which is different from the other types of programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is characterized by a process in which fatal lipids from lipid peroxidation accumulate in cells and eventually lead to cell death. Alcohol-related liver disease (ALD) is a type of liver injury caused by excessive alcohol intake. Alcohol-related liver disease is a broad-spectrum disease category, which includes fatty liver, steatohepatitis, hepatitis, cirrhosis, and hepatocellular tumors. Recent studies have found that ferroptosis is involved in the pathological development of non-viral liver diseases. Therefore, ferroptosis may be an ideal target for the treatment of non-viral liver diseases. In this review article, we will elaborate the molecular mechanism and regulatory mechanism of ferroptosis, explore the key role of ferroptosis in the Alcohol-related liver disease process, and summarize the existing targeted ferroptosis drugs and their feasibility for the treatment of Alcohol-related liver disease.
铁死亡是一种新的铁依赖性细胞死亡模式，它不同于其他类型的程序性细胞死亡，如凋亡、坏死和自噬。铁死亡的特征是脂质过氧化产生的致命脂质在细胞内积累，最终导致细胞死亡的过程。酒精性肝病（ALD）是一种由过量饮酒引起的肝损伤。酒精性肝病是一个广谱疾病类别，包括脂肪肝、脂肪性肝炎、肝炎、肝硬化和肝细胞肿瘤。最近的研究发现，铁死亡参与了非病毒性肝病的病理发展。因此，铁死亡可能是治疗非病毒性肝病的理想靶点。在这篇综述文章中，我们将阐述铁死亡的分子机制和调控机制，探讨铁死亡在酒精性肝病进程中的关键作用，并总结现有的靶向铁死亡药物及其治疗酒精性肝病的可行性。
