脂滴和脂肪酸诱导的脂毒性：简而言之。
Lipid droplets and fatty acid-induced lipotoxicity: in a nutshell.
机构信息
Department of Biological Sciences, Wayne State University, Detroit, MI, USA.
出版信息
FEBS Lett. 2024 May;598(10):1207-1214. doi: 10.1002/1873-3468.14808. Epub 2024 Jan 28.
Abstract
Lipid droplets (LDs) are fat storage organelles that are conserved from bacteria to humans. LDs are broken down to supply cells with fatty acids (FAs) that can be used as an energy source or membrane synthesis. An overload of FAs disrupts cellular functions and causes lipotoxicity. Thus, by acting as hubs for storing excess fat, LDs prevent lipotoxicity and preserve cellular homeostasis. LD synthesis and turnover have to be precisely regulated to maintain a balanced lipid distribution and allow for cellular adaptation during stress. Here, we discuss how prolonged exposure to excess lipids affects cellular functions, and the roles of LDs in buffering cellular stress focusing on lipotoxicity.
摘要
脂滴（LDs）是从细菌到人类都保守的脂肪储存细胞器。LDs 被分解以向细胞提供脂肪酸（FAs），这些脂肪酸可以用作能量来源或膜合成。FA 的过载会破坏细胞功能并导致脂毒性。因此，LD 作为储存多余脂肪的中心，可防止脂毒性并维持细胞内环境稳定。为了维持平衡的脂质分布并在压力下允许细胞适应，LD 的合成和周转必须精确调节。在这里，我们讨论了长期暴露于过量脂质如何影响细胞功能，以及 LDs 在缓冲细胞应激（特别是脂毒性）方面的作用。
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