上皮-间质转化过程中可变剪接的调控。
Regulation of Alternative Splicing during Epithelial-Mesenchymal Transition.
机构信息
Lester and Sue Smith Breast Center, Department of Molecular and Human Genetics, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Integrative Molecular and Biomedical Sciences Graduate Program, Baylor College of Medicine, Houston, Texas, USA.
出版信息
Cells Tissues Organs. 2022;211(2):238-251. doi: 10.1159/000518249. Epub 2021 Jul 8.
Alternative splicing is an essential mechanism of gene regulation, giving rise to remarkable protein diversity in higher eukaryotes. Epithelial-mesenchymal transition (EMT) is a developmental process that plays an essential role in metazoan embryogenesis. Recent studies have revealed that alternative splicing serves as a fundamental layer of regulation that governs cells to undergo EMT. In this review, we summarize recent findings on the functional impact of alternative splicing in EMT and EMT-associated activities. We then discuss the regulatory mechanisms that control alternative splicing changes during EMT.
选择性剪接是基因调控的一种重要机制，在高等真核生物中产生了显著的蛋白质多样性。上皮-间充质转化 (EMT) 是一个发育过程，在多细胞动物胚胎发生中起着至关重要的作用。最近的研究表明，选择性剪接是一种基本的调控层，控制细胞经历 EMT。在这篇综述中，我们总结了选择性剪接在 EMT 及其相关活动中的功能影响的最新发现。然后，我们讨论了控制 EMT 过程中选择性剪接变化的调节机制。
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