Zhang Xiao-Li, Chen Ming-Hui, Geng Shi-Tao, Yu Juehua, Kuang Yi-Qun, Luo Hua-You, Wang Kun-Hua
NHC Key Laboratory of Drug Addiction Medicine, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, Kunming, China.
Scientific Research Laboratory Center, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Front Pharmacol. 2021 Jul 19;12:570520. doi: 10.3389/fphar.2021.570520. eCollection 2021.
Gastrointestinal probiotics play an important role in maintaining intestinal bacteria homeostasis. They might benefit people with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), which remains a global health challenge. However, there is a controversy regarding the efficacy of probiotics for the treatment of AIDS. This study systematically reviewed the evidence of the effects of existing probiotic interventions on AIDS and sought to provide information on the role of probiotics in the treatment of HIV/AIDS patients. A meta-analysis of studies identified by screening multiple databases was performed using a fixed-effects model in Review Manager 5.2 software. The meta-analysis showed that probiotics could reduce the incidence of AIDS-related diarrhea (RR = 0.60 (95% CI: 0.44-0.82), = 0.001). The short-term use of probiotics (supplementation duration shorter than 30 days) did not reduce the incidence of diarrhea (RR = 0.76 (95% CI: 0.51-1.14), = 0.19), while the long-term use of probiotics (supplementation duration longer than 30 days) reduced diarrhea (RR = 0.47 (95% CI: 0.29-0.76), = 0.002). Probiotics had no effect on CD4 cell counts in HIV/AIDS patients (MD = 21.24 (95% CI: -12.95-55.39), = 0.22). Our data support that probiotics were associated with an obvious reduction in AIDS-related diarrhea, which indicates the need for additional research on this potential preventive strategy for AIDS.
胃肠道益生菌在维持肠道细菌稳态方面发挥着重要作用。它们可能对人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者有益，而HIV/AIDS仍然是一项全球性的健康挑战。然而，关于益生菌治疗艾滋病的疗效存在争议。本研究系统回顾了现有益生菌干预措施对艾滋病影响的证据，并试图提供有关益生菌在治疗HIV/AIDS患者中作用的信息。使用Review Manager 5.2软件中的固定效应模型对通过筛选多个数据库确定的研究进行了荟萃分析。荟萃分析表明，益生菌可降低艾滋病相关腹泻的发生率（RR = 0.60（95%CI：0.44 - 0.82），P = 0.001）。短期使用益生菌（补充持续时间短于30天）并未降低腹泻发生率（RR = 0.76（95%CI：0.51 - 1.14），P = 0.19），而长期使用益生菌（补充持续时间长于30天）可降低腹泻发生率（RR = 0.47（95%CI：0.29 - 0.76），P = 0.002）。益生菌对HIV/AIDS患者的CD4细胞计数没有影响（MD = 21.24（95%CI： - 12.95 - 55.39），P = 0.22）。我们的数据支持益生菌与艾滋病相关腹泻的明显减少有关，这表明需要对这种潜在的艾滋病预防策略进行更多研究。
