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艾滋病病毒/艾滋病益生菌研究的当前趋势与未来方向

Current trends and future directions in probiotics research for HIV/AIDS.

作者信息

Cui Xinxin, Xie Zhanpeng, Wu Zhen, Xu Li-Qin

机构信息

Medical School of Shihezi University, Xinjiang, China.

Yueyang County People's Hospital, Yueyang, China.

出版信息

Front Microbiol. 2024 Dec 27;15:1444552. doi: 10.3389/fmicb.2024.1444552. eCollection 2024.

DOI:10.3389/fmicb.2024.1444552
PMID:39802658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11718315/
Abstract

AIM

This study aims to comprehensively and systematically review the current status of research on probiotics and HIV/AIDS, while also exploring future research hotspots and trends in this domain.

METHODS

The Web of Science (WoS) Core Collection database was queried up until May 13, 2024, to retrieve relevant literature on probiotics and HIV/AIDS. Utilizing CiteSpace, VOSviewers, and Bibliometrix software, scientific achievements and research frontiers in this field were analyzed.

RESULTS

As of May 14, 2024, a total of 90 articles was included in. The publication output in this area peaked in 2017, with a subsequent decline in the number of articles post-2019. The United States emerged as the leading country in terms of article count (32 articles), with The University of Western Ontario being the institution with the highest publication output. Dr. Reid G contributed the most articles (12 articles). In addition to key terms, high-frequency keywords included immune activation, inflammation, and microbial translocation. The burst analysis of keywords suggests that vaccines may become a focal point of future research.

CONCLUSION

Future research hotspots and trends should focus on elucidating the types of probiotics, intervention timing, and optimal strains (in terms of mixing ratios) in the context of HIV/AIDS. Furthermore, exploration into the role of probiotic metabolites, such as short-chain fatty acids, in vaccine development is warranted.

摘要

目的

本研究旨在全面、系统地综述益生菌与艾滋病毒/艾滋病的研究现状，同时探索该领域未来的研究热点和趋势。

方法

检索截至2024年5月13日的科学网（WoS）核心合集数据库，以获取有关益生菌与艾滋病毒/艾滋病的相关文献。利用CiteSpace、VOSviewers和Bibliometrix软件分析该领域的科学成就和研究前沿。

结果

截至2024年5月14日，共纳入90篇文章。该领域的发表量在2017年达到峰值，2019年后文章数量有所下降。就文章数量而言，美国是领先国家（32篇文章），西安大略大学是发表量最高的机构。里德·G博士贡献的文章最多（12篇）。除了关键术语外，高频关键词还包括免疫激活、炎症和微生物易位。关键词的突现分析表明，疫苗可能成为未来研究的重点。

结论

未来的研究热点和趋势应聚焦于阐明艾滋病毒/艾滋病背景下益生菌的类型、干预时机和最佳菌株（混合比例方面）。此外，有必要探索益生菌代谢产物，如短链脂肪酸，在疫苗开发中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/763ed22b5f6b/fmicb-15-1444552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/fc635fc5b259/fmicb-15-1444552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/ace7108605f2/fmicb-15-1444552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/6598ba7de629/fmicb-15-1444552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/b05364a103aa/fmicb-15-1444552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/ac647be4ec4e/fmicb-15-1444552-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/2b96243397b0/fmicb-15-1444552-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/763ed22b5f6b/fmicb-15-1444552-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/fc635fc5b259/fmicb-15-1444552-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/ace7108605f2/fmicb-15-1444552-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/6598ba7de629/fmicb-15-1444552-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/b05364a103aa/fmicb-15-1444552-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/ac647be4ec4e/fmicb-15-1444552-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/2b96243397b0/fmicb-15-1444552-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ee9/11718315/763ed22b5f6b/fmicb-15-1444552-g007.jpg

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