Hill M J
St Mark's Hospital Research Department, London, United Kingdom.
Ann Acad Med Singap. 1987 Jul;16(3):402-7.
Colorectal cancer, one of the "diseases of western civilisation", is a multistage process in which the first stage is the formation of a benign adenoma, followed by adenoma growth, increasing severity of epithelial dysplasia, and finally carcinoma. Adenoma formation is caused by environmental factors, probably acting primarily on a genetically predisposed fraction of the population. Adenoma growth is probably caused by a bacterial metabolite of the bile acids, the concentration of which is increased by dietary fat or meat and decreased by fibre. This probably acts in concert with hormonal factors. Similar factors are probably responsible for the increasing severity of epithelial dysplasia.
结直肠癌是“西方文明病”之一，是一个多阶段过程，第一阶段是良性腺瘤的形成，随后是腺瘤生长、上皮发育异常严重程度增加，最终发展为癌。腺瘤的形成是由环境因素引起的，这些因素可能主要作用于具有遗传易感性的一部分人群。腺瘤生长可能是由胆汁酸的一种细菌代谢产物引起的，饮食中的脂肪或肉类会增加其浓度，而纤维则会降低其浓度。这可能与激素因素共同起作用。类似的因素可能导致上皮发育异常严重程度的增加。
