Arvind Varun, Huang Alice H
Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Department of Orthopedic Surgery, Columbia University, New York, NY, United States.
Front Bioeng Biotechnol. 2021 Jul 19;9:719047. doi: 10.3389/fbioe.2021.719047. eCollection 2021.
Tendon injuries are common and debilitating, with non-regenerative healing often resulting in chronic disease. While there has been considerable progress in identifying the cellular and molecular regulators of tendon healing, the role of inflammation in tendon healing is less well understood. While inflammation underlies chronic tendinopathy, it also aids debris clearance and signals tissue repair. Here, we highlight recent findings in this area, focusing on the cells and cytokines involved in reparative inflammation. We also discuss findings from other model systems when research in tendon is minimal, and explore recent studies in the treatment of human tendinopathy to glean further insights into the immunobiology of tendon healing.
肌腱损伤很常见且会使人衰弱，非再生性愈合常常导致慢性病。虽然在确定肌腱愈合的细胞和分子调节因子方面已经取得了相当大的进展，但炎症在肌腱愈合中的作用仍不太清楚。虽然炎症是慢性肌腱病的基础，但它也有助于清除碎片并发出组织修复信号。在这里，我们重点介绍该领域的最新发现，重点关注参与修复性炎症的细胞和细胞因子。当肌腱研究很少时，我们还讨论了其他模型系统的发现，并探索了近期治疗人类肌腱病的研究，以进一步深入了解肌腱愈合的免疫生物学。
