代谢调控在损伤后肌腱炎症和愈合中的作用。
Metabolic Regulation of Tendon Inflammation and Healing Following Injury.
机构信息
Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Ave, Box 665, Rochester, NY, 14642, USA.
出版信息
Curr Rheumatol Rep. 2021 Feb 10;23(3):15. doi: 10.1007/s11926-021-00981-4.
Abstract
PURPOSE OF REVIEW
This review seeks to provide an overview of the role of inflammation and metabolism in tendon cell function, tendinopathy, and tendon healing. We have summarized the state of knowledge in both tendon and enthesis.
RECENT FINDINGS
Recent advances in the field include a substantial improvement in our understanding of tendon cell biology, including the heterogeneity of the tenocyte environment during homeostasis, the diversity of the cellular milieu during in vivo tendon healing, and the effects of inflammation and altered metabolism on tendon cell function in vitro. In addition, the mechanisms by which altered systemic metabolism, such as diabetes, disrupts tendon homeostasis continue to be better understood. A central conclusion of this review is the critical need to better define fundamental cellular and signaling mechanisms of inflammation and metabolism during tendon homeostasis, tendinopathy, and tendon healing in order to identify therapies to enhance or maintain tendon function.
摘要
目的综述
本篇综述旨在概述炎症和代谢在肌腱细胞功能、腱病和肌腱愈合中的作用。我们总结了肌腱和腱附丽组织两方面的现有知识。
最近的发现
该领域的最新进展包括对肌腱细胞生物学的认识有了实质性的提高，包括在稳态时的肌腱细胞环境的异质性、体内肌腱愈合时细胞微环境的多样性，以及炎症和代谢改变对体外肌腱细胞功能的影响。此外，代谢改变（如糖尿病）如何破坏肌腱稳态的机制也得到了更好的理解。这篇综述的一个重要结论是，需要更好地定义炎症和代谢在肌腱稳态、腱病和肌腱愈合过程中的基本细胞和信号机制，以确定增强或维持肌腱功能的治疗方法。
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