Department of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of General Surgery, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Environ Toxicol. 2021 Nov;36(11):2278-2290. doi: 10.1002/tox.23341. Epub 2021 Aug 5.
Zinc finger protein 367 (ZNF367) has been documented as a new cancer-related protein that exerts a pivotal role in the carcinogenesis of multiple cancers. However, whether ZNF367 plays a role in colorectal cancer has not been fully understood. Our data showed that ZNF367 expression was higher in colorectal cancer. Depletion of ZNF367 weakened the proliferative and invasive capabilities of colorectal cancer cells. Up-regulation of ZNF367 enhanced the in vitro malignant features of colorectal cancer cells. Knockdown of ZNF367 impeded the activation of Yes-associated protein (YAP1). Reactivation of YAP1 reversed the ZNF367-knockdown-mediated anticancer effects. Suppression of YAP1 significantly abolished ZNF367-overexpression-induced tumor-promotion effects. Depletion of ZNF367 repressed the tumorigenicity of colorectal cancer cells in vivo. These findings demonstrate that ZNF367 is overexpressed in colorectal cancer and acts as a potential tumor-promoter that contributes to the proliferation and invasion of colorectal cancer by enhancing the activation of YAP1 signaling.
锌指蛋白 367（ZNF367）已被证实为一种新的癌症相关蛋白，在多种癌症的发生中发挥关键作用。然而，ZNF367 是否在结直肠癌中发挥作用尚不完全清楚。我们的数据显示，ZNF367 在结直肠癌中的表达更高。敲低 ZNF367 削弱了结直肠癌细胞的增殖和侵袭能力。上调 ZNF367 增强了结直肠癌细胞的体外恶性特征。敲低 ZNF367 抑制了 Yes 相关蛋白（YAP1）的激活。YAP1 的再激活逆转了 ZNF367 敲低介导的抗癌作用。抑制 YAP1 显著消除了 ZNF367 过表达诱导的肿瘤促进作用。敲低 ZNF367 抑制了结直肠癌细胞在体内的致瘤性。这些发现表明，ZNF367 在结直肠癌中过表达，并作为一种潜在的肿瘤促进剂，通过增强 YAP1 信号的激活，促进结直肠癌细胞的增殖和侵袭。
