赛拉嗪在矮种马体内的药代动力学：育亨宾的影响。

Pharmacokinetics of xylazine in ponies: influence of yohimbine.

作者信息

Dyer D C, Hsu W H, Lloyd W E

机构信息

Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Iowa State University, Ames 50011.

出版信息

Arch Int Pharmacodyn Ther. 1987 Sep;289(1):5-10.

PMID:3435205

Abstract

Twenty healthy ponies were given i.v. 1.1 mg/kg of xylazine from 2 manufacturers and the pharmacokinetic parameters calculated from the disposition curves. The disposition curves for the 2 commercial preparations were not different. Yohimbine, an antagonist of the pharmacologic effects produced by xylazine, did not alter the disposition of xylazine in the plasma. A single i.v. bolus of xylazine was completely described in 17 of 20 animals by the biexponential equation: Cp = 1.30e(-0.3955t) + 0.58e(-0.033t) where Cp represents the concentration of xylazine in the plasma at time t (min). The t1/2 beta was 75 +/- 13 min and whole body clearance was 18.9 +/- 1.5 (ml/min.kg).

摘要

给20匹健康小马静脉注射来自2个厂家的1.1毫克/千克甲苯噻嗪，并根据处置曲线计算药代动力学参数。两种市售制剂的处置曲线没有差异。育亨宾是一种可拮抗甲苯噻嗪药理作用的拮抗剂，它不会改变甲苯噻嗪在血浆中的处置。20只动物中有17只的单次静脉推注甲苯噻嗪可用双指数方程完全描述：Cp = 1.30e(-0.3955t) + 0.58e(-0.033t)，其中Cp表示时间t（分钟）时血浆中甲苯噻嗪的浓度。t1/2β为75±13分钟，全身清除率为18.9±1.5（毫升/分钟·千克）。