Department of Earth and Environmental Sciences, Williamson Research Centre for Molecular Environmental Science, University of Manchester, Manchester M13 9PL, UK.
School of Science, Engineering & Environment, University of Salford, Salford M5 4WT, UK; Mahavir Cancer Institute and Research Center, Patna, India.
Ecotoxicol Environ Saf. 2021 Oct 15;223:112572. doi: 10.1016/j.ecoenv.2021.112572. Epub 2021 Aug 2.
Epidemiological studies have associated chronic exposure to arsenic (As) from drinking water with increased risk of hypertension. However, evidence of an association between As exposure from food and hypertension risks is sparse. To quantify the association between daily As intake from both food (rice, wheat and potatoes) and drinking water (As) along with total exposure (As) and hypertension risks in a study population in Bihar, India, we conducted an individual level cross-sectional analysis between 2017 and 2019 involving 150 participants. Arsenic intake variables and three indicators of hypertension risks (general hypertension, low-density lipoprotein (LDL) and high-density lipoprotein (HDL)) were derived, and any relationship was quantified using a series of crude and multivariable log-linear or logistic regression models. The prevalence of general hypertension was 40% for the studied population. The median level of HDL was 45 mg/dL while median value of LDL was 114 mg/dL. Apart from a marginally significant positive relationship between As intake from rice and the changes of LDL (p-value = 0.032), no significant positive association between As intake and hypertension risks could be ascertained. In fact, As was found to be associated with lower risks of general hypertension and higher levels of HDL (p-value = 0.020 and 0.010 respectively) whilst general hypertension was marginally associated with lower As (p-value = 0.043). Due to limitations regarding study design and residual confounding, all observed marginal associations should be treated with caution.
流行病学研究表明，长期饮用含砷（As）的水与高血压风险增加有关。然而，食物中砷暴露与高血压风险之间的关联证据很少。为了在印度比哈尔邦的一个研究人群中定量评估食物（大米、小麦和土豆）和饮用水（As）中每日砷摄入以及总暴露（As）与高血压风险之间的关联，我们在 2017 年至 2019 年期间进行了一项涉及 150 名参与者的个体水平横断面分析。我们得出了砷摄入量变量和高血压风险的三个指标（一般高血压、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）），并使用一系列原始和多变量对数线性或逻辑回归模型来量化任何关系。研究人群中一般高血压的患病率为 40%。HDL 的中位数水平为 45mg/dL，而 LDL 的中位数水平为 114mg/dL。除了大米中砷摄入与 LDL 变化之间存在略微显著的正相关关系（p 值=0.032）外，我们无法确定砷摄入与高血压风险之间存在显著的正相关关系。事实上，我们发现砷与一般高血压风险降低和 HDL 水平升高有关（p 值分别为 0.020 和 0.010），而一般高血压与较低的砷水平有关（p 值为 0.043）。由于研究设计和残余混杂的限制，所有观察到的边缘关联都应谨慎对待。
