Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Parkinsonism Relat Disord. 2021 Sep;90:44-48. doi: 10.1016/j.parkreldis.2021.07.028. Epub 2021 Jul 29.
Serum neurofilament light chain (NfL) levels are associated with disease severity in early Parkinson's disease (PD). We assessed the association of serum NfL with motor and cognitive function and decline in advanced PD patients.
NfL concentrations were analyzed with single molecule array (Simoa) assay in serum of 289 PD patients with advanced disease from the single-center prospective observational biobank study Biomarkers in Parkinson's disease (MARK-PD). Motor and cognitive symptoms were assessed with MDS-UPDRS III, Hoehn&Yahr stages and Montreal Cognitive Assessment (MoCA) at baseline and during 520 [364, 674] days of follow-up.
Serum NfL concentrations were associated with Hoehn&Yahr stages. During follow-up, baseline NfL levels were associated with time to cognitive decline in adjusted Cox regression models (hazard ratio: 3.23; 95% CI [1.16, 9.00], P < 0.025). Serum NfL was associated with NT-proBNP in adjusted models linking neuronal and cardiac damage in advanced PD patients.
In advanced PD patients, serum NfL concentrations are associated with motor function, cognitive decline and subclinical cardiac damage.
血清神经丝轻链（NfL）水平与早期帕金森病（PD）的疾病严重程度相关。我们评估了血清 NfL 与晚期 PD 患者的运动和认知功能及下降的相关性。
在单中心前瞻性观察性生物库研究“帕金森病生物标志物（MARK-PD）”中，使用单分子阵列（Simoa）分析法分析了 289 名晚期 PD 患者血清中的 NfL 浓度。在基线和 520[364,674]天的随访期间，使用 MDS-UPDRS III、Hoehn&Yahr 分期和蒙特利尔认知评估（MoCA）评估运动和认知症状。
血清 NfL 浓度与 Hoehn&Yahr 分期相关。在随访期间，调整后的 Cox 回归模型显示，基线 NfL 水平与认知下降的时间相关（危险比：3.23；95%CI[1.16,9.00]，P<0.025）。在将神经元和心脏损伤相关联的调整模型中，血清 NfL 与 NT-proBNP 相关。
在晚期 PD 患者中，血清 NfL 浓度与运动功能、认知下降和亚临床心脏损伤相关。
