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术前糖化血红蛋白(HbA1c)>8%与腰椎手术不良预后相关:密歇根脊柱手术改善协作研究。

Preoperative HbA1c > 8% Is Associated With Poor Outcomes in Lumbar Spine Surgery: A Michigan Spine Surgery Improvement Collaborative Study.

机构信息

Department of Neurological Surgery, Henry Ford Hospital, Detroit, Michigan, USA.

Department of Public Health Services, Henry Ford Hospital, Detroit, Michigan, USA.

出版信息

Neurosurgery. 2021 Oct 13;89(5):819-826. doi: 10.1093/neuros/nyab294.

Abstract

BACKGROUND

Preoperative hemoglobin A1c (HbA1c) is a useful screening tool since a significant portion of diabetic patients in the United States are undiagnosed and the prevalence of diabetes continues to increase. However, there is a paucity of literature analyzing comprehensive association between HbA1c and postoperative outcome in lumbar spine surgery.

OBJECTIVE

To assess the prognostic value of preoperative HbA1c > 8% in patients undergoing elective lumbar spine surgery.

METHODS

The Michigan Spine Surgery Improvement Collaborative (MSSIC) database was queried to track all elective lumbar spine surgeries between January 2018 and December 2019. Cases were divided into 2 cohorts based on preoperative HbA1c level (≤8% and >8%). Measured outcomes include any complication, surgical site infection (SSI), readmission (RA) within 30 d (30RA) and 90 d (90RA) of index operation, patient satisfaction, and the percentage of patients who achieved minimum clinically important difference (MCID) using Patient-Reported Outcomes Measurement Information System.

RESULTS

We captured 4778 patients in this study. Our multivariate analysis demonstrated that patients with HbA1c > 8% were more likely to experience postoperative complication (odds ratio [OR] 1.81, 95% CI 1.20-2.73; P = .005) and be readmitted within 90 d of index surgery (OR 1.66, 95% CI 1.08-2.54; P = .021). They also had longer hospital stay (OR 1.12, 95% CI 1.03-1.23; P = .009) and were less likely to achieve functional improvement after surgery (OR 0.64, 95% CI 0.44-0.92; P = .016).

CONCLUSION

HbA1c > 8% is a reliable predictor of poor outcome in elective lumbar spine surgery. Clinicians should consider specialty consultation to optimize patients' glycemic control prior to surgery.

摘要

背景

术前糖化血红蛋白(HbA1c)是一种有用的筛查工具,因为美国相当一部分糖尿病患者未被诊断出,并且糖尿病的患病率还在持续上升。然而,目前关于 HbA1c 与腰椎手术术后结果之间的综合关联的文献却很少。

目的

评估术前 HbA1c>8%的患者接受择期腰椎手术的预后价值。

方法

密歇根脊柱手术改进协作组(MSSIC)数据库被用来追踪 2018 年 1 月至 2019 年 12 月期间所有的择期腰椎手术病例。根据术前 HbA1c 水平(≤8%和>8%)将病例分为 2 组。测量结果包括任何并发症、手术部位感染(SSI)、术后 30d(30RA)和 90d(90RA)内的再入院、患者满意度以及采用患者报告的结果测量信息系统(PROMIS)达到最小临床重要差异(MCID)的患者比例。

结果

本研究共纳入 4778 例患者。多变量分析显示,HbA1c>8%的患者术后发生并发症的可能性更高(比值比 [OR] 1.81,95%置信区间 [CI] 1.20-2.73;P=0.005),且在索引手术 90d 内再次入院的可能性更高(OR 1.66,95% CI 1.08-2.54;P=0.021)。他们的住院时间也更长(OR 1.12,95% CI 1.03-1.23;P=0.009),且术后功能改善的可能性更小(OR 0.64,95% CI 0.44-0.92;P=0.016)。

结论

HbA1c>8%是择期腰椎手术不良预后的可靠预测因子。临床医生应考虑在手术前进行专科会诊,以优化患者的血糖控制。

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