Shen Li, Zhang Yuan, Su Yiliang, Weng Dong, Zhang Fen, Wu Qin, Chen Tao, Li Qiuhong, Zhou Ying, Hu Yang, Jiang Xing, Jin Xiaofeng, Zhang Aihong, Li Huiping
Medical College of Soochow University, Suzhou, China; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
Ann Palliat Med. 2021 Jul;10(7):7289-7297. doi: 10.21037/apm-21-71.
The aim of our study is to investigate the impact of the simple breathing exercises (LHP's respiratory rehabilitation for pulmonary fibrosis, LHP's RRPF) on patients with idiopathic pulmonary fibrosis (IPF).
(I) The safety and effectiveness of LHP's RRPF were first verified in 20 healthy individuals. (II) A total of 101 patients with IPF administrated in Shanghai Pulmonary Hospital between January 2015 and May 2017 were screened, and 82 cases were randomly assigned to receive a 12-month LHP's RRPF program (exercise group) or usual medical care (control group). Lung function, chest X-ray, 6-minute walk distance (6MWD), quality of life (St. George's Respiratory Questionnaire, SGRQ), and EKG were measured at the 6th and 12th month during the trial.
At the 6th month visit, the exercise group showed improved SGRQ score and lung function parameters (FVC, FEV1, and DLCO). At the 12th months visit, the exercise group had significantly improved SGRQ score, 6MWD, and lung function (FVC, FEV1, and DLCO) compared to the control group (P<0.05). No obvious adverse events occurred in the exercise group. The incidence of acute exacerbation and one-year mortality were 7.69% and 2.56%, respectively in the exercise group, which were lower than those (20.9% and 9.3%, respectively) in the control group.
LHP's RRPF can delay the pulmonary function decline of patients with IPF and improve their quality of life. This breathing exercise may be an adjunct to pulmonary rehabilitation for IPF.
我们研究的目的是调查简单呼吸练习（李氏肺纤维化呼吸康复训练，LHP的RRPF）对特发性肺纤维化（IPF）患者的影响。
（I）首先在20名健康个体中验证LHP的RRPF的安全性和有效性。（II）筛选了2015年1月至2017年5月在上海肺科医院就诊的101例IPF患者，82例被随机分配接受为期12个月的LHP的RRPF计划（运动组）或常规医疗护理（对照组）。在试验的第6个月和第12个月测量肺功能、胸部X线、6分钟步行距离（6MWD）、生活质量（圣乔治呼吸问卷，SGRQ）和心电图。
在第6个月就诊时，运动组的SGRQ评分和肺功能参数（FVC、FEV1和DLCO）有所改善。在第12个月就诊时，与对照组相比，运动组的SGRQ评分、6MWD和肺功能（FVC、FEV1和DLCO）有显著改善（P<0.05）。运动组未发生明显不良事件。运动组急性加重发生率和一年死亡率分别为7.69%和2.56%，低于对照组（分别为20.9%和9.3%）。
LHP的RRPF可以延缓IPF患者肺功能下降并改善其生活质量。这种呼吸练习可能是IPF肺康复的辅助手段。
