Lu HuiLun, Zhang Qi, Long Jiao
The Department of Respiratory Medicine, Shenzhen Longgang Second People's Hospital, Shenzhen, Guangdong, China.
Department of Anesthesiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Front Nutr. 2024 Jul 24;11:1399038. doi: 10.3389/fnut.2024.1399038. eCollection 2024.
Protein is crucial for the rehabilitation of patients with chronic obstructive pulmonary disease (COPD), and appropriate daily protein intake is essential for COPD patients. However, the specific role of protein intake in COPD and its impact on mortality remain uncertain. This study aims to ascertain the relationship between protein intake and mortality in COPD patients.
This investigation included 522 adult COPD patients from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2018, with a focus on evaluating protein intake. Multivariate Cox proportional hazard models were constructed to analyze the correlation between protein intake and the prognosis of COPD patients. Additionally, the restricted cubic spline (RCS) was employed to investigate the potential non-linear association between protein intake and mortality.
A total of 522 patients with COPD were categorized into 4 groups based on the quartiles of protein intake: Q1 (< 25th percentile, 11.7-48.5 gm), Q2 (25-50th percentile, 48.5-67.7 gm), Q3 (50-75th percentile, 67.7-94.3 gm), and Q4 (≥ 75th percentile, 94.3-266.6 gm). Cox regression analysis revealed a significant trend in the p value of the Q3 group compared to the Q1 group when adjusting for other variables. The RCS-fitted Cox regression model indicated no non-linear relationship between protein intake levels and COPD mortality.
There is no evidence of a non-linear relationship between protein intake and all-cause mortality in COPD patients. Further investigation is warranted to comprehend the intricate relationship between protein intake and COPD outcomes.
蛋白质对慢性阻塞性肺疾病（COPD）患者的康复至关重要，COPD患者每日摄入适量蛋白质必不可少。然而，蛋白质摄入在COPD中的具体作用及其对死亡率的影响仍不确定。本研究旨在确定COPD患者蛋白质摄入量与死亡率之间的关系。
本调查纳入了2013年至2018年美国国家健康与营养检查调查（NHANES）中的522例成年COPD患者，重点评估蛋白质摄入量。构建多变量Cox比例风险模型，分析蛋白质摄入量与COPD患者预后的相关性。此外，采用限制立方样条（RCS）研究蛋白质摄入量与死亡率之间潜在的非线性关联。
根据蛋白质摄入量的四分位数，522例COPD患者共分为4组：Q1（<第25百分位数，11.7 - 48.5克）、Q2（第25 - 50百分位数，48.5 - 67.7克）、Q3（第50 - 75百分位数，67.7 - 94.3克）和Q4（≥第75百分位数，94.3 - 266.6克）。Cox回归分析显示，在调整其他变量后，Q3组与Q1组相比，p值有显著趋势。RCS拟合的Cox回归模型表明，蛋白质摄入水平与COPD死亡率之间不存在非线性关系。
没有证据表明COPD患者蛋白质摄入量与全因死亡率之间存在非线性关系。有必要进一步研究以了解蛋白质摄入量与COPD结局之间的复杂关系。
