利用定量成像技术确定肥胖青少年患者下丘脑炎症与焦虑和抑郁之间的相关性。

Using quantitative imaging to determine the correlation between hypothalamic inflammation and anxiety and depression in young patients with obesity.

作者信息

Dong Guan-Zhong, Yang Hao-Jun, Jiao Yu-Wen, Zhang Qiao-Yang, Ma Yi, Zhu Shu-Min, Zhang Li-Hao, Zhang Min, Yao Tian, Cao Yin, Tang Li-Ming

机构信息

Department of Neurology, Changzhou No.2 People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.

出版信息

Ann Palliat Med. 2021 Jul;10(7):8043-8050. doi: 10.21037/apm-21-1480.

DOI:10.21037/apm-21-1480

PMID:34353089

Abstract

BACKGROUND

To investigate the incidence of anxiety and depressive disorders in young adults with obesity and the correlation between the severity of these disorders and hypothalamic inflammation.

METHODS

The severity of anxiety and depressive disorders was assessed using the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), respectively. Hypothalamic inflammation was evaluated by measuring the hypothalamus/amygdala (H/A) signal intensity (SI) ratio in T2-weighted phase quantitative magnetic resonance imaging (MRI).

RESULTS

The incidence of depressive disorders in young (18-45 years) patients with obesity (n=66) was higher than that in the control group (n=44); anxiety disorder incidence did not differ significantly between groups. The bilateral H/A SI ratio in the obesity group was significantly higher than that in the control group. In the obesity group, there was no significant correlation between bilateral H/A SI ratio and body mass index (BMI) (right: r=-0.145, P=0.721; left: r=0.102, P=0.415) or SAS scores (right: r=-0.118, P=0.444; left: r=-0.295, P=0.052); SDS scores were significantly correlated with left H/A SI ratio (r=-0.353, P=0.019), but not right H/A SI ratio (r=-0.031, P=0.843).

CONCLUSIONS

Patients with obesity had a higher incidence of depressive disorders. Left hypothalamus inflammation may be one of the links between obesity and depressive disorders.

摘要

背景

探讨肥胖青年成人焦虑和抑郁障碍的发病率，以及这些障碍的严重程度与下丘脑炎症之间的相关性。

方法

分别使用自评焦虑量表（SAS）和自评抑郁量表（SDS）评估焦虑和抑郁障碍的严重程度。通过测量T2加权相位定量磁共振成像（MRI）中的下丘脑/杏仁核（H/A）信号强度（SI）比值来评估下丘脑炎症。

结果

肥胖的年轻（18 - 45岁）患者（n = 66）中抑郁障碍的发病率高于对照组（n = 44）；两组间焦虑障碍发病率无显著差异。肥胖组的双侧H/A SI比值显著高于对照组。在肥胖组中，双侧H/A SI比值与体重指数（BMI）（右侧：r = -0.145，P = 0.721；左侧：r = 0.102，P = 0.415）或SAS评分（右侧：r = -0.118，P = 0.444；左侧：r = -0.295，P = 0.052）之间无显著相关性；SDS评分与左侧H/A SI比值显著相关（r = -0.353，P = 0.019），但与右侧H/A SI比值无关（r = -0.031，P = 0.843）。