Department of Pediatrics, Université Laval, Centre de Recherche de l'Institut Universitaire de Cardiologie et Pneumologie de Québec, 2725 Chemin Ste-Foy, Québec, Québec G1V 4G5, Canada.
Department of Pediatrics, Université Laval, Centre de Recherche de l'Institut Universitaire de Cardiologie et Pneumologie de Québec, 2725 Chemin Ste-Foy, Québec, Québec G1V 4G5, Canada.
Clin Chest Med. 2021 Sep;42(3):391-405. doi: 10.1016/j.ccm.2021.04.002.
The respiratory system of women and men develops and functions in distinct neuroendocrine milieus. Despite differences in anatomy and neural control, homeostasis of arterial blood gases is ensured in healthy individuals regardless of sex. This convergence in function differs from the sex-based differences observed in many respiratory diseases. Sleep-disordered breathing (SDB) results mainly from episodes of upper airway closure. This complex and multifactorial respiratory disorder shows significant sexual dimorphism in its clinical manifestations and comorbidities. Guided by recent progress from basic research, this review discusses the hypothesis that stress is necessary to reveal the sexual dimorphism of SDB.
女性和男性的呼吸系统在不同的神经内分泌环境中发育和运作。尽管解剖结构和神经控制存在差异，但健康个体的动脉血气平衡得以确保，而与性别无关。这种功能上的趋同与许多呼吸系统疾病中观察到的基于性别的差异不同。睡眠呼吸障碍（SDB）主要是由上呼吸道关闭引起的。这种复杂的多因素呼吸系统疾病在其临床表现和合并症方面表现出显著的性别二态性。本综述以基础研究的最新进展为指导，讨论了应激是揭示 SDB 性别二态性的必要条件这一假说。
