Assessment of status by examination of gastric mucosal patterns: diagnostic accuracy of white-light endoscopy and narrow-band imaging.

OBJECTIVES

infection is a common cause of chronic gastritis worldwide and an established risk factor for developing gastric malignancy. The endoscopic appearances predicting status are an ongoing area of research, as are their diagnostic accuracies. This study aimed to establish the diagnostic accuracy of several mucosal features predictive of negative status and formulate a simple prediction model for use at the time of endoscopy.

DESIGN

Patients undergoing high-definition upper gastrointestinal (GI) endoscopy without magnification were recruited prospectively. During the endoscopy, the presence or absence of specific endoscopic findings was noted. Sydney protocol biopsies were used as the diagnostic reference standard, and urease test if taken. The results informed a logistic regression model used to produce a simple diagnostic approach. This model was subsequently validated using a further cohort of 30 patients.

RESULTS

153 patients were recruited and completed the study protocol. The prevalence of active infection was 18.3% (28/153). The overall diagnostic accuracy of the simple prediction model was 80.0%, and 100% of patients with active infection were correctly classified. The presence of regular arrangement of collecting venules (RAC) showed a positive predictive value for naïve status of 90.7%, rising to 93.6% for patients under the age of 60.

CONCLUSION

A simple endoscopic model may be accurate for predicting status of a patient, and the need for biopsy-based tests. The presence of RAC in the stomach is an accurate predictor of negative status, particularly in patients under the age of 60.

TRIAL REGISTRATION NUMBER

The study was registered with ClinicalTrials.gov, No. NCT02385045.