Wani Bilal Ahmad, Shehjar Faheem, Shah Sonaullah, Koul Ajaz, Yusuf Adfar, Murtaza Masqooba, Singh Rajni, Althobaiti Fayez, Aldhahrani Adil, Afroze Dil
Advanced Centre for Human Genetics, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, J&K, India.
Amity Institute of Microbial Biotechnology, Amity University, Uttar Pradesh, Noida, U.P, India.
Saudi J Biol Sci. 2021 Aug;28(8):4210-4216. doi: 10.1016/j.sjbs.2021.06.029. Epub 2021 Jun 17.
Tuberculosis (TB) caused by (MTB) is a chronic infectious disease. is an important cytokine imparting resistance to mycobacterial diseases. It is believed that and play divergent roles in the host immune system against infection. is an important inhibitory cytokine and helps balancing the inflammatory and immune responses. is involved in down regulation of Th1 cytokines, MHC class II antigen and co-stimulatory molecular expression on macrophages, while results in macrophage activation allowing them to exert the microbicidal role. The objectives were to find out the association of and single nucleotide polymorphisms (SNPs) with extrapulmonary tuberculosis in ethnic Kashmiri population. A total of 100 extrapulmonary tuberculosis cases and 102 healthy controls were analyzed for and SNPs using Allele-Specific PCR. We found a significant association of genotype with extrapulmonary tuberculosis (p = 0.006) and in case of we found a significant association with extrapulmonary tuberculosis under recessive model (GG vs GA + AA) (p = 0.03) in Kashmiri population. and have a significant association with extrapulmonary tuberculosis in ethnic Kashmiri population.
由结核分枝杆菌（MTB）引起的结核病（TB）是一种慢性传染病。[此处原文缺失关键细胞因子名称]是赋予对分枝杆菌疾病抵抗力的一种重要细胞因子。据信，[此处原文缺失关键细胞因子名称]和[此处原文缺失关键细胞因子名称]在宿主免疫系统对抗[此处原文缺失关键病原体名称]感染中发挥不同作用。[此处原文缺失关键细胞因子名称]是一种重要的抑制性细胞因子，有助于平衡炎症和免疫反应。[此处原文缺失关键细胞因子名称]参与下调巨噬细胞上的Th1细胞因子、MHC II类抗原和共刺激分子表达，而[此处原文缺失关键细胞因子名称]则导致巨噬细胞活化，使其发挥杀菌作用。目的是在克什米尔族人群中找出[此处原文缺失关键细胞因子名称]和[此处原文缺失关键细胞因子名称]单核苷酸多态性（SNP）与肺外结核的关联。使用等位基因特异性PCR对总共100例肺外结核病例和102名健康对照进行了[此处原文缺失关键细胞因子名称]和[此处原文缺失关键细胞因子名称]SNP分析。我们发现[此处原文缺失关键细胞因子名称]基因型与肺外结核有显著关联（p = 0.006），对于[此处原文缺失关键细胞因子名称]，在克什米尔人群的隐性模型（GG与GA + AA）下发现与肺外结核有显著关联（p = 0.03）。[此处原文缺失关键细胞因子名称]和[此处原文缺失关键细胞因子名称]与克什米尔族人群的肺外结核有显著关联。
