Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis.

Tuberculosis (TB) caused by (MTB) is a chronic infectious disease. is an important cytokine imparting resistance to mycobacterial diseases. It is believed that and play divergent roles in the host immune system against infection. is an important inhibitory cytokine and helps balancing the inflammatory and immune responses. is involved in down regulation of Th1 cytokines, MHC class II antigen and co-stimulatory molecular expression on macrophages, while results in macrophage activation allowing them to exert the microbicidal role. The objectives were to find out the association of and single nucleotide polymorphisms (SNPs) with extrapulmonary tuberculosis in ethnic Kashmiri population. A total of 100 extrapulmonary tuberculosis cases and 102 healthy controls were analyzed for and SNPs using Allele-Specific PCR. We found a significant association of genotype with extrapulmonary tuberculosis (p = 0.006) and in case of we found a significant association with extrapulmonary tuberculosis under recessive model (GG vs GA + AA) (p = 0.03) in Kashmiri population. and have a significant association with extrapulmonary tuberculosis in ethnic Kashmiri population.