Tanaka Tomonari, Zhou Yiting, Tamoto Chihiro, Kurebayashi Yuuki, Takahashi Tadanobu, Suzuki Takashi
1 Department of Biobased Materials Science, Graduate School of Science and Technology, Kyoto Institute of Technology.
2 Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka.
J Appl Glycosci (1999). 2017 May 20;64(2):43-48. doi: 10.5458/jag.jag.JAG-2017_003. eCollection 2017.
A glycopolymer bearing α2,3-linked sialyltrisaccharides was synthesized by living radical polymerization using a glycomonomer prepared by a protecting-group-free process, direct azidation of the free sialyllactose, and subsequent azide-alkyne cycloaddition. The prepared glycopolymer with pendant 3´-sialyllactose moieties strongly interacted with both avian and human influenza viruses analyzed by the hemagglutination inhibition assay and the quartz crystal microbalance method.
通过活性自由基聚合反应，使用无保护基法制备的糖单体、游离唾液酸乳糖的直接叠氮化以及随后的叠氮化物-炔烃环加成反应，合成了带有α2,3-连接的唾液酸三糖的糖聚合物。通过血凝抑制试验和石英晶体微天平方法分析，所制备的带有3´-唾液酸乳糖侧链部分的糖聚合物与禽流感病毒和人流感病毒均有强烈相互作用。
