Department of Virology, Research Institute for Microbial Diseases (BIKEN), Osaka University, Osaka, Japan.
Trends Microbiol. 2012 Jan;20(1):11-20. doi: 10.1016/j.tim.2011.10.003. Epub 2011 Dec 5.
Highly pathogenic avian influenza A virus subtype H5N1 has been endemic in some bird species since its emergence in 1996 and its ecology, genetics and antigenic properties have continued to evolve. This has allowed diverse virus strains to emerge in endemic areas with altered receptor specificity, including a new H5 sublineage with enhanced binding affinity to the human-type receptor. The pandemic potential of H5N1 viruses is alarming and may be increasing. We review here the complex dynamics and changing nature of the H5N1 virus that may contribute to the emergence of pandemic strains.
高致病性禽流感病毒 H5N1 自 1996 年出现以来，一直存在于某些鸟类物种中，其生态学、遗传学和抗原特性仍在不断演变。这使得不同的病毒株在地方性流行地区出现，受体特异性发生改变，包括与人类型受体结合亲和力增强的新型 H5 亚谱系。H5N1 病毒的大流行潜力令人震惊，而且可能还在增加。我们在此回顾了 H5N1 病毒的复杂动态和不断变化的性质，这些可能导致大流行株的出现。
