胰腺癌患者辅助放疗的生存获益与差异
Survival Benefits and Disparities in Adjuvant Radiation Therapy for Patients with Pancreatic Cancer.
作者信息
Baig Mirza Zain, Filkins Alexandra, Khan Muhammad, Saif Muhammad Wasif, Aziz Hassan
机构信息
Department of Surgery, Rudy Ruggles Biomedical Research Institute, Nuvance Health, USA.
Department of Surgery, University of Southern California, Keck School of Medicine, CA, USA.
出版信息
JOP. 2021;22(2):36-41. Epub 2021 Mar 30.
BACKGROUND
The effects of adjuvant radiation therapy on pancreatic cancer outcomes after resection are not well defined in the literature.
METHODS
We abstracted data from the Surveillance, Epidemiology, and End Result (SEER) database to explore the impact of adjuvant radiation on cancer-specific survival in pancreatic cancer patients who received surgical resection.
RESULTS
A total of 10,224 patients met our inclusion criteria with 6768 (66.2%) patients treated with surgery only and 3456 (33.8%) treated with surgery plus adjuvant radiation. Surgery followed by adjuvant radiation was associated with significantly improved survival (HR: 0.753, CI: 0.718-0.789, p<0.001). Additionally, female gender and married status were both independently associated with better survival (p<0.05), while advanced age, Caucasian race, higher TNM stage, and higher grade had worse survival outcomes (p<0.05) Asian and Spanish-Hispanic-Latino patients were less likely to receive adjuvant radiotherapy (p<0.05).
CONCLUSION
Adjuvant radiation was associated with significantly improved survival after resection for pancreatic cancer. There are significant differences in the patient populations who receive adjuvant radiation.
背景
辅助放疗对胰腺癌切除术后预后的影响在文献中尚无明确界定。
方法
我们从监测、流行病学和最终结果（SEER）数据库中提取数据，以探讨辅助放疗对接受手术切除的胰腺癌患者癌症特异性生存的影响。
结果
共有10224例患者符合我们的纳入标准，其中6768例（66.2%）仅接受手术治疗，3456例（33.8%）接受手术加辅助放疗。手术加辅助放疗与显著改善的生存率相关（风险比：0.753，置信区间：0.718 - 0.789，p<0.001）。此外，女性性别和已婚状态均与更好的生存率独立相关（p<0.05），而高龄、白种人、更高的TNM分期和更高的分级则生存率较差（p<0.05）。亚洲和西班牙裔 - 拉丁裔患者接受辅助放疗的可能性较小（p<0.05）。
结论
辅助放疗与胰腺癌切除术后生存率显著提高相关。接受辅助放疗的患者群体存在显著差异。
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