Duregon Eleonora, Vieira Ligo Teixeira Camila, Palliyaguru Dushani L, Rudderow Annamaria L, Hoffmann Victoria, Bernier Michel, Price Nathan L, Camandola Simonetta, de Cabo Rafael
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Division of Veterinary Resources, National Institutes of Health, Bethesda, MD 20892, USA.
Aging Pathobiol Ther. 2020;2(4):219-222. doi: 10.31491/apt.2020.12.043.
A female UM-HET3 mouse from the Study of Longitudinal Aging in Mice (SLAM) was euthanized at 164 weeks of age due to hind limb weakness. Necropsy and histological analysis revealed that the most probable cause of the clinical finding was the compression of the thoracolumbar segment of the spinal cord by herniated intervertebral disks. In addition, a spontaneous chordoma was incidentally found in the coccygeal bones. Given the rarity of this type of tumor, bio-clinical annotations acquired throughout lifespan, detailed histopathological assessment, and comparative clinical-pathological correlations for this mouse are presented and discussed.
一只来自小鼠纵向衰老研究（SLAM）的雌性UM-HET3小鼠在164周龄时因后肢无力而实施安乐死。尸检和组织学分析表明，临床发现的最可能原因是椎间盘突出压迫脊髓胸腰段。此外，在尾骨中偶然发现了一个自发性脊索瘤。鉴于这种类型肿瘤的罕见性，本文呈现并讨论了该小鼠在整个生命周期中获得的生物临床注释、详细的组织病理学评估以及比较临床病理相关性。
