Olstad Katie J, Imai Denise M, Keesler Rebekah I, Reader Rachel, Morrison John H, Roberts Jeffery A, Capitanio John P, Didier Elizabeth S, Kuroda Marcelo J, Simmons Heather, Salimi Shabnam, Mattison Julie A, Ikeno Yuji, Ladiges Warren
California National Primate Research Center, University of California, Davis, CA, USA.
Comparative Pathology Laboratory, University of California, Davis, CA, USA.
Aging Pathobiol Ther. 2020;2(1):16-19. doi: 10.31491/apt.2020.03.008.
A geropathology grading platform (GGP) for assessing age-related lesions has been established and validated for in inbred strain of mice. Because nonhuman primates (NHPs) share significant similarities in aging and spontaneous chronic diseases with humans, they provide excellent translational value for correlating histopathology with biological and pathological events associated with increasing age. Descriptive age-associated pathology has been described for rhesus macaques and marmosets, but a grading platform similar to the mouse GGP does not exist. The value of these NHP models is enhanced by considerable historical data from clinical, bio-behavioral, and social domains that align with health span in these animals. Successful adaptation of the mouse GGP for NHPs will include 1) expanding the range of organs examined; 2) standardizing necropsy collection, tissue trimming, and descriptive lesion terminology; 3) expanding beyond rhesus macaques and marmosets to include other commonly used NHPs in research; and 4) creating a national resource for age-related pathology to complement the extensive in-life datasets. Adaptation of the GGP to include translational models other than mice will be crucial to advance geropathology designed to enhance aging research.
一个用于评估与年龄相关病变的老年病理学分级平台（GGP）已经建立，并在近交系小鼠中得到验证。由于非人灵长类动物（NHPs）在衰老和自发性慢性疾病方面与人类有显著相似之处，它们为将组织病理学与与年龄增长相关的生物学和病理事件相关联提供了极好的转化价值。恒河猴和狨猴的描述性年龄相关病理学已经被描述，但不存在类似于小鼠GGP的分级平台。这些非人灵长类动物模型的价值因来自临床、生物行为和社会领域的大量历史数据而得到提升，这些数据与这些动物的健康寿命相一致。成功地将小鼠GGP应用于非人灵长类动物将包括：1）扩大检查器官的范围；2）规范尸检收集、组织修整和描述性病变术语；3）从恒河猴和狨猴扩展到包括研究中其他常用的非人灵长类动物；4）创建一个与年龄相关病理学的国家资源，以补充广泛的生命期数据集。使GGP适应包括小鼠以外的转化模型对于推进旨在加强衰老研究的老年病理学至关重要。
