胰腺癌立体定向放疗的新潜在选择
New Potential Options for SBRT in Pancreatic Cancer.
作者信息
Ghaly Maged, Gogineni Emile, Herman Joseph, Saif Muhammad W
机构信息
Northwell Health Cancer Institute, Lake Success, NY 11042, USA.
出版信息
Cancer Med J. 2021 Mar;4(Suppl 3):41-50. Epub 2021 Feb 18.
Abstract
Stereotactic body radiotherapy (SBRT) is an emerging treatment option for patients with pancreatic cancer, as it can provide a therapeutic benefit with significant advantages for patients' quality of life over standard conventional chemoradiation (CRT). The objective of this review is to present alternative clinical settings in which SBRT may benefit patients with pancreatic cancer. These include palliation of pain, elderly patients who are not surgical candidates, local therapy in oligometastatic cases and salvaging local failures after surgery or external beam radiation. We will review these individually and provide supporting literature for each.
摘要
立体定向体部放疗（SBRT）是胰腺癌患者一种新兴的治疗选择，因为与标准的传统放化疗（CRT）相比，它能提供治疗益处，对患者生活质量有显著优势。本综述的目的是介绍SBRT可能使胰腺癌患者受益的其他临床情况。这些情况包括疼痛缓解、不适合手术的老年患者、寡转移病例的局部治疗以及手术或外照射后挽救局部复发。我们将分别对这些情况进行综述，并为每种情况提供支持性文献。
相似文献
1
New Potential Options for SBRT in Pancreatic Cancer.
Cancer Med J. 2021 Mar;4(Suppl 3):41-50. Epub 2021 Feb 18.
2
Stereotactic Body Radiation Therapy for Pancreatic Cancer.
Cancer J. 2016 Jul-Aug;22(4):290-5. doi: 10.1097/PPO.0000000000000206.
3
Re-irradiation with stereotactic body radiation therapy as a novel treatment option for isolated local recurrence of pancreatic cancer after multimodality therapy: experience from two institutions.
J Gastrointest Oncol. 2013 Dec;4(4):343-51. doi: 10.3978/j.issn.2078-6891.2013.044.
4
Pancreatic cancer and SBRT: A new potential option?
Rep Pract Oncol Radiother. 2015 Sep-Oct;20(5):377-84. doi: 10.1016/j.rpor.2015.05.008. Epub 2015 Jun 28.
5
Stereotactic body radiation therapy in pancreatic cancer: the new frontier.
Expert Rev Anticancer Ther. 2014 Dec;14(12):1461-75. doi: 10.1586/14737140.2014.952286. Epub 2014 Sep 3.
6
Five-Fraction Stereotactic Body Radiation Therapy (SBRT) and Chemotherapy for the Local Management of Metastatic Pancreatic Cancer.
J Gastrointest Cancer. 2018 Jun;49(2):116-123. doi: 10.1007/s12029-016-9909-2.
7
Erratum to: "Pancreatic cancer and SBRT: A new potential option?" [Rep. Pract. Oncol. Radiother. 20 (2015) 377-384].
Rep Pract Oncol Radiother. 2015 Nov-Dec;20(6):491. doi: 10.1016/j.rpor.2015.10.001. Epub 2015 Nov 19.
8
Reirradiation spine stereotactic body radiation therapy for spinal metastases: systematic review.
J Neurosurg Spine. 2017 Oct;27(4):428-435. doi: 10.3171/2017.2.SPINE16976. Epub 2017 Jul 14.
9
Stereotactic body radiotherapy vs conventionally fractionated chemoradiation in locally advanced pancreatic cancer: A multicenter case-control study (PAULA-1).
Cancer Med. 2020 Nov;9(21):7879-7887. doi: 10.1002/cam4.3330. Epub 2020 Sep 10.
10
Clinical Effects of Stereotactic Body Radiation Therapy Targeting the Primary Tumor of Liver-Only Oligometastatic Pancreatic Cancer.
Front Oncol. 2021 May 27;11:659987. doi: 10.3389/fonc.2021.659987. eCollection 2021.
引用本文的文献
1
Recent Advances and Challenges in the Treatment of Advanced Pancreatic Cancer: An Update on Completed and Ongoing Clinical Trials.
Cancers (Basel). 2025 Apr 14;17(8):1319. doi: 10.3390/cancers17081319.
2
Dose-Escalated SBRT for Borderline and Locally Advanced Pancreatic Cancer: Resectability Rate and Pathological Results of a Multicenter Prospective Study.
Cancers (Basel). 2025 Jan 9;17(2):191. doi: 10.3390/cancers17020191.
3
Early outcomes of MR-guided SBRT for patients with recurrent pancreatic adenocarcinoma.
Radiat Oncol. 2024 May 29;19(1):65. doi: 10.1186/s13014-024-02457-y.
4
Dose-escalated SBRT for borderline and locally advanced pancreatic cancer. Feasibility, safety and preliminary clinical results of a multicenter study.
Clin Transl Radiat Oncol. 2024 Feb 23;45:100753. doi: 10.1016/j.ctro.2024.100753. eCollection 2024 Mar.
5
Pancreatic Cancer: Challenges and Opportunities in Locoregional Therapies.
Cancers (Basel). 2022 Aug 31;14(17):4257. doi: 10.3390/cancers14174257.
6
Auranofin and Pharmacologic Ascorbate as Radiomodulators in the Treatment of Pancreatic Cancer.
Antioxidants (Basel). 2022 May 14;11(5):971. doi: 10.3390/antiox11050971.
本文引用的文献
1
Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach.
Pract Radiat Oncol. 2020 Nov-Dec;10(6):e495-e507. doi: 10.1016/j.prro.2020.01.012. Epub 2020 Feb 13.
2
The Evolving Field of Stereotactic Body Radiation Therapy in Pancreatic Cancer.
Pancreas (Fairfax). 2019;3(1):9-14. doi: 10.17140/POJ-3-110. Epub 2019 Nov 6.
3
Australasian Gastrointestinal Trials Group (AGITG) and Trans-Tasman Radiation Oncology Group (TROG) Guidelines for Pancreatic Stereotactic Body Radiation Therapy (SBRT).
Pract Radiat Oncol. 2020 May-Jun;10(3):e136-e146. doi: 10.1016/j.prro.2019.07.018. Epub 2019 Nov 21.
4
Safety and efficacy of locoregional therapy for metastatic pancreatic ductal adenocarcinoma to the liver: a single-center experience.
J Gastrointest Oncol. 2019 Aug;10(4):688-694. doi: 10.21037/jgo.2019.03.13.
5
Oligometastases in pancreatic cancer (Synchronous resections of hepatic oligometastatic pancreatic cancer: Disputing a principle in a time of safe pancreatic operations in a retrospective multicenter analysis).
Ann Gastroenterol Surg. 2019 Apr 29;3(4):373-377. doi: 10.1002/ags3.12255. eCollection 2019 Jul.
6
Surgery for Recurrent Pancreatic Cancer: Is It Effective?
Cancers (Basel). 2019 Jul 16;11(7):991. doi: 10.3390/cancers11070991.
7
Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial.
Lancet. 2019 May 18;393(10185):2051-2058. doi: 10.1016/S0140-6736(18)32487-5. Epub 2019 Apr 11.
8
Stereotactic body radiation therapy for locally advanced pancreatic cancer.
PLoS One. 2019 Apr 12;14(4):e0214970. doi: 10.1371/journal.pone.0214970. eCollection 2019.
9
Stereotactic radiotherapy of pancreatic cancer: a systematic review on pain relief.
J Pain Res. 2018 Oct 4;11:2169-2178. doi: 10.2147/JPR.S167994. eCollection 2018.
10
Radiotherapy of pancreatic cancer in older patients: A systematic review.
J Geriatr Oncol. 2019 Jul;10(4):534-539. doi: 10.1016/j.jgo.2018.09.007. Epub 2018 Sep 28.
Zotero 插件