Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Food Funct. 2021 Sep 20;12(18):8694-8703. doi: 10.1039/d1fo01711j.
The mold has been used as a natural food coloring agent and food additive for more than 1000 years in Asian countries. In Chinese herbology, it was also used for easing digestion and antiseptic effects. Through a thorough investigation of a citrinin-free strain: BCRC 38110, four azaphilones, three benzenoids, one benzofuranone, one 5',6'-dihydrospiro[isochromane-1,2'-pyran]-4'(3')-one derivative, two steroids, and six tetralones have been successfully identified. Among them, monapyridine A (1), monatetralones A-E (2-6), and monabenzofuranone (7) were first reported. Their structures were characterized by 1D and 2D NMR, UV, IR, and HRESIMS analyses. With a series of bioactivity screening, monascuspirolide B (14) and ergosterol peroxide (16) exhibited concentration-dependent attenuation of the paclitaxel-induced neurite damage of mouse dorsal root ganglion neurons. The interleukin (IL)-1β-induced release of inflammatory cytokines IL-8 and tumor necrosis factor (TNF)-α in human chondrosarcoma cells was inhibited by monapurpureusone (8) and monascuspirolide B (14). Altogether, BCRC 38110 possessed potentials as natural therapeutics against inflammatory osteoarthritis and paclitaxel-induced neurotoxicity.
该霉菌在亚洲国家已作为天然食用色素和食品添加剂使用了 1000 多年。在中国草药学中，它也被用于助消化和防腐作用。通过对无桔青霉素菌株 BCRC 38110 的彻底研究，成功鉴定出了四种吖啶酮、三种苯衍生物、一种苯并呋喃酮、一种 5'，6'-二氢螺[异苯并吡喃-1,2'-吡喃]-4'（3'）-酮衍生物、两种甾体和六种四氢酮。其中，首次报道了单吡啶 A（1）、单四氢酮 A-E（2-6）和单苯并呋喃酮（7）。通过 1D 和 2D NMR、UV、IR 和 HRESIMS 分析对其结构进行了表征。通过一系列生物活性筛选，发现红曲菌素 B（14）和麦角甾醇过氧化物（16）对紫杉醇诱导的小鼠背根神经节神经元轴突损伤具有浓度依赖性抑制作用。单阿朴啡酮（8）和红曲菌素 B（14）抑制人软骨肉瘤细胞中白细胞介素（IL）-1β诱导的炎症细胞因子 IL-8 和肿瘤坏死因子（TNF）-α的释放。总之，BCRC 38110 具有作为天然治疗剂治疗炎症性骨关节炎和紫杉醇诱导的神经毒性的潜力。
