利用单克隆抗体对一种来自乳腺癌细胞的新型肿瘤相关抗原进行鉴定。
Characterization of a new tumor associated antigen from mammary carcinoma cells by monoclonal antibodies.
作者信息
Czuppon A B
机构信息
Biotec Diagnostica International GmbH, Hannover.
出版信息
Biochem Int. 1987 Aug;15(2):359-72.
PMID:3435529
Abstract
A new tumor associated glycoprotein antigen was identified in the soluble fraction of adenocarcinoma of the mammary gland. Immunoprecipitation with a monoclonal antibody revealed an antigen with a molecular weight of 300.000 daltons and a pI of 4.3. Immunoblotting of sera from patients with mammary carcinoma indicated the presence of the antigen at various concentrations. This antigen was not detected in any of the normal sera tested so far and was absent on non-malignant breast tissue.
摘要
在乳腺腺癌的可溶性组分中鉴定出一种新的肿瘤相关糖蛋白抗原。用单克隆抗体进行免疫沉淀显示，该抗原分子量为300,000道尔顿，等电点为4.3。对乳腺癌患者血清进行免疫印迹分析表明，该抗原以不同浓度存在。在目前检测的所有正常血清中均未检测到这种抗原，且在非恶性乳腺组织中也不存在。
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