Tabriz Navid, Gloy Kilian, Schantzen Astrid, Fried Dennis, Weyhe Dirk, Uslar Verena
University Hospital for Visceral Surgery, Pius-Hospital Oldenburg, Carl von Ossietzky University, Oldenburg, Germany.
Endocr Connect. 2021 Sep 1;10(9):1065-1072. doi: 10.1530/EC-21-0114.
Validation of a German version of the ThyPRO-39 questionnaire for quality of life (QoL) in patients with benign thyroid diseases.
Internal consistency, retest reliability, and validity were to be assessed in a test-retest study.
The ThyPRO-39 was translated based on standard methodology. A sample of 98 patients with benign thyroid diseases was tested with the ThyPRO-39de and the generic EuroQol 5D-5L. Forty-four patients with stable symptoms after 2 weeks formed the repeated measures sample. Cronbach's alpha was calculated for the ThyPRO-39de composite score and for each disease-specific scale. Intraclass correlations between the original and the repeated measures sample were calculated for each scale as well as Pearson correlations between various ThyPRO scales and the EuroQol. T-tests were used to test for differences in the goiter and hyperthyroid symptom scales between relevant patient groups and other patients.
Internal consistency was between satisfactory and good, except for two scales (tiredness and cosmetic complaints/appearance). The test-retest correlation was between 0.62 and 0.8 for most scales, but below 0.5 for two scales (tiredness and impaired social life). There were significant correlations between the EuroQol index score and most aspects of the ThyPRO-39de. Only the hyperthyroid symptoms scale was specific for the relevant patient group (Graves' disease).
The ThyPRO-39de may be recommended for use in clinical and research settings, especially with regards to the composite score. However, the underlying thyroid disease should always be kept in mind when interpreting the test results. A larger sample would be needed to implement further improvements.
验证德语版ThyPRO - 39问卷用于评估良性甲状腺疾病患者的生活质量（QoL）。
在一项重测研究中评估内部一致性、重测信度和效度。
根据标准方法对ThyPRO - 39进行翻译。98例良性甲状腺疾病患者样本接受ThyPRO - 39德语版和通用的欧洲五维健康量表（EuroQol 5D - 5L）测试。2周后症状稳定的44例患者组成重复测量样本。计算ThyPRO - 39德语版综合得分及各疾病特异性量表的Cronbach's α系数。计算每个量表在原始样本和重复测量样本之间的组内相关系数，以及不同ThyPRO量表与欧洲五维健康量表之间的Pearson相关系数。采用t检验比较相关患者组与其他患者在甲状腺肿和甲亢症状量表上的差异。
除两个量表（疲劳和美容问题/外观）外，内部一致性令人满意至良好。大多数量表的重测相关性在0.62至0.8之间，但两个量表（疲劳和社交生活受损）低于0.5。欧洲五维健康量表指数得分与ThyPRO - 39德语版的大多数方面存在显著相关性。只有甲亢症状量表对相关患者组（格雷夫斯病）具有特异性。
ThyPRO - 39德语版可推荐用于临床和研究环境，特别是综合得分方面。然而，在解释测试结果时应始终牢记潜在的甲状腺疾病。需要更大的样本量来进一步改进。
