Zhong Jun-Song, Yang Zi-Xin, Ding Cheng-Lin, Huang Ya-Feng, Zhao Yi, Yan Hong, Ye Ke-Yin
Key Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou 350108, China.
BayRay Innovation Center, Shenzhen Bay Laboratory (SZBL), Guangdong 518000, China.
J Org Chem. 2021 Nov 19;86(22):16162-16170. doi: 10.1021/acs.joc.1c01261. Epub 2021 Aug 6.
Electrocarboxylation of organic halides is one of the most investigated electrochemical approaches for converting thermodynamically inert carbon dioxide (CO) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives, we have developed a highly efficient electrochemical desulfonylative carboxylation protocol. Such a strategy takes advantage of CO as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.
有机卤化物的电羧化反应是将热力学惰性的二氧化碳（CO₂）转化为高附加值羧酸的研究最多的电化学方法之一。通过将有机卤化物转化为它们的砜衍生物，我们开发了一种高效的电化学脱磺酰基羧化反应方案。这种策略利用CO₂作为丰富的C1构建单元，在温和的反应条件下简便地制备多功能羧酸，包括非甾体抗炎药布洛芬。
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