von Kries R, Kreppel S, Becker A, Tangermann R, Göbel U
Department of Paediatrics, University of Düsseldorf, Federal Republic of Germany.
Arch Dis Child. 1987 Sep;62(9):938-40. doi: 10.1136/adc.62.9.938.
The effect of prophylaxis with oral vitamin K (1 mg vitamin K1 given with the first feed) on the rate of detection of acarboxyprothrombin (PIVKA II) and factor II clotting concentration [corrected] were analysed. Introducing such prophylaxis reduced the rates of detection of PIVKA II concentration [corrected] on day 5 from 48% to zero. None of the babies given prophylaxis had factor II clotting concentration [corrected] below 40%, compared with 34 of 95 babies not given prophylaxis. This study has important implications in the prophylaxis of both classical and late onset haemorrhagic disease of the newborn.
分析了口服维生素K（首次喂养时给予1毫克维生素K1）预防对异常凝血酶原（PIVKA II）检测率和凝血因子II浓度[校正后]的影响。采用这种预防措施可使第5天PIVKA II浓度[校正后]的检测率从48%降至零。接受预防的婴儿中，没有一个的凝血因子II浓度[校正后]低于40%，而未接受预防的95名婴儿中有34名低于40%。这项研究对新生儿经典型和晚发型出血性疾病的预防具有重要意义。
