Galle P, Giudicelli C P, Nebout T, Baglin A, Fries D
Laboratoire de Biophysique de la Faculté de Médecine de Créteil.
Ann Pathol. 1987;7(3):163-70.
The livers of 7 hemodialyzed patients have been studied by electron microscopy and electron probe X-ray microanalysis. In 6 patients dialyzed for a long time (at least 39 months), aluminum has been detected in high concentrations in phagolysosomes of hepatocytes; in these lysosomes aluminum is associated with phosphorus. In 2 of these 6 patients, a very large number of aluminum inclusion bodies were found inside hepatocytes and this aluminum accumulation was associated with severe ultrastructural lesions of the cells. In one patient dialyzed during a short period (4 months) no aluminum accumulation has been observed. In none of the 7 patients was aluminum accumulation detected inside the Küpffer cells. These observations show that the cell which accumulates aluminum in the liver of dialyzed patients is the hepatocyte and not the Küpffer cell and that this accumulation may be associated with serious hepatocellular lesions.
通过电子显微镜和电子探针X射线微分析对7名血液透析患者的肝脏进行了研究。在6名长期透析（至少39个月）的患者中，已在肝细胞的吞噬溶酶体中检测到高浓度的铝；在这些溶酶体中，铝与磷相关联。在这6名患者中的2名患者中，在肝细胞内发现了大量的铝包涵体，并且这种铝蓄积与细胞的严重超微结构病变相关。在一名短期透析（4个月）的患者中，未观察到铝蓄积。在这7名患者中，均未在库普弗细胞内检测到铝蓄积。这些观察结果表明，在透析患者肝脏中蓄积铝的细胞是肝细胞而非库普弗细胞，并且这种蓄积可能与严重的肝细胞病变相关。
